| Name | lactate dehydrogenase (protein family or complex) |
|---|---|
| Synonyms | LDH; lactate dehydrogenase; lactate dehydrogenases |
| Name | pentachlorophenol |
|---|---|
| CAS | 2,3,4,5,6-pentachlorophenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7080100 | Verma SR, Rani S, Dalela RC: Effects of pentachlorophenate on enzymes of energy metabolism in tissues of Notopterus notopterus. Toxicol Lett. 1982 Feb;10(2-3):297-302. Effect of sublethal concentrations (0.0083, 0.0055, 0.0041, 0.0033 and 0.0028 mg/l) of penta-chlorophenate (Na-PCP) on the enzymes SDH, PDH and LDH in brain, liver and gills of Notopterus notopterus after 15 ad 30 days exposure were studied. |
4(0,0,0,4) | Details |
| 12223198 | Tugiyono, Gagnon MM: Metabolic disturbances in fish exposed to pentachlorophenate (NaPCP) and 3,3',4,4',5-pentachlorobiphenyl (PCB126), individually or combined. Comp Biochem Physiol C Toxicol Pharmacol. 2002 Aug;132(4):425-35. In the liver, cytochrome c oxidase (CCO) activity was enhanced by the treatments while citrate synthase (CS) activity remained unchanged and lactate dehydrogenase (LDH) activity was increased in the NaPCP treatment only. |
1(0,0,0,1) | Details |
| 6764429 | Kerkvliet NI, Baecher-Steppan L, Claycomb AT, Craig AM, Sheggeby GG: Immunotoxicity of technical pentachlorophenol (PCP-T): depressed humoral immune responses to T-dependent and T-independent antigen stimulation in PCP-T exposed mice. Fundam Appl Toxicol. 1982 Mar-Apr;2(2):90-9. Liver weight and serum lactate dehydrogenase (LD-L) and alanine aminotransferase (ALT) levels were significantly elevated during PCP-T exposure and returned to control levels after a 4-6 week recovery period. |
1(0,0,0,1) | Details |
| 8157216 | Hasheminejad G, Caldwell J: Genotoxicity of the alkenylbenzenes alpha- and beta-asarone, myristicin and elimicin as determined by the UDS assay in cultured rat hepatocytes. Food Chem Toxicol. 1994 Mar;32(3):223-31. Cytotoxicity was assessed by lactate dehydrogenase leakage. The genotoxicity of the asarones is inhibited by the cytochrome P-450 inhibitor cimetidine but the sulfotransferase inhibitor pentachlorophenol (PCP) is without effect. |
1(0,0,0,1) | Details |
| 11566584 | Repetto G, Jos A, Hazen MJ, Molero ML, del Peso A, Salguero M, Castillo PD, Rodriguez-Vicente MC, Repetto M: A test battery for the ecotoxicological evaluation of pentachlorophenol. . Toxicol In Vitro. 2001 Aug-Oct;15(4-5):503-9. Neutral red uptake, cell growth, MTT reduction, lactate dehydrogenase leakage and activity were studied in the salmonid fish cell line RTG-2, derived from the gonad of rainbow trout. |
1(0,0,0,1) | Details |
| 9084885 | Suzuki T, Komatsu M, Isono H: Cytotoxicity of organochlorine pesticides and lipid peroxidation in isolated rat hepatocytes. Biol Pharm Bull. 1997 Mar;20(3):271-4. We examined 9 pesticides of 3 different representative chemical families, chlorinated aromatic fungicides (pentachlorophenol (PCP), pentachloronitrobenzene (PCNB), chlorothalonil, fthalide), polyhaloalkylated thio fungicides (dichlofluanid, captan) and diphenyl ether herbicide (2,4-dichlorophenyl ether (NIP), 4-nitrophenyl2,4,6-trichlorophenyl ether (CNP), chlomethoxynil). Chlorothalonil, dichlofluanid and captan were the most potent cytotoxicants evaluated by lactate dehydrogenase (LDH) leakage. |
1(0,0,0,1) | Details |
| 7387397 | Gotz R, Schwarz LR, Greim H: Effects of pentachlorophenol and 2,4,6-trichlorophenol on the disposition of sulfobromophthalein and respiration of isolated liver cells. Arch Toxicol. 1980 Mar;44(1-3):147-55. |
0(0,0,0,0) | Details |
| 11679267 | Young SJ, Hart JP, Dowman AA, Cowell DC: The non-specific inhibition of enzymes by environmental pollutants: a study of a model system towards the development of electrochemical biosensor arrays. Biosens Bioelectron. 2001 Dec;16(9-12):887-94. Previous research has shown that lactate dehydrogenase (LDH) was competitively inhibited by pentachlorophenol (PCP) and a modified assay produced a detection limit of 1 microM (270 microg l (-1)). |
81(1,1,1,1) | Details |