| Name | transthyretin |
|---|---|
| Synonyms | ATTR; HsT2651; PALB; Prealbumin; TBPA; TTR; Transthyretin; Transthyretin precursor… |
| Name | pentachlorophenol |
|---|---|
| CAS | 2,3,4,5,6-pentachlorophenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2043046 | Van den Berg KJ, van Raaij JA, Bragt PC, Notten WR: Interactions of halogenated industrial chemicals with transthyretin and effects on thyroid hormone levels in vivo. Arch Toxicol. 1991;65(1):15-9. Examples from these chemical groups, e.g. pentachlorophenol, 2,4-dichlorophenoxybutyric acid, dinoseb and bromoxynil, also reduced plasma TT4 levels in rats. |
3(0,0,0,3) | Details |
| 12553426 | Yamauchi K, Eguchi R, Shimada N, Ishihara A: The effects of endocrine-disrupting chemicals on thyroid hormone binding to Xenopus laevis transthyretin and thyroid hormone receptor. Clin Chem Lab Med. 2002 Dec;40(12):1250-6. The xTTR's relative affinities for diethylstilbestrol, pentachlorophenol and ioxynil were 10 (-1)- to 10 (-2)-fold less than that for T3. |
2(0,0,0,2) | Details |
| 12581883 | Ishihara A, Sawatsubashi S, Yamauchi K: Endocrine disrupting chemicals: interference of thyroid hormone binding to transthyretins and to thyroid hormone receptors. Mol Cell Endocrinol. 2003 Jan 31;199(1-2):105-17. Scatchard analysis revealed DES, pentachlorophenol and ioxynil as competitive inhibitors of [125I] T (3) binding to cTTR and bTTR. |
2(0,0,0,2) | Details |
| 2393944 | van den Berg KJ: Interaction of chlorinated phenols with binding sites of human transthyretin, albumin and thyroid binding globulin. Chem Biol Interact. 1990;76(1):63-75. The ranking in competition was pentachlorophenol (PCP) greater than trichlorophenols greater than dichlorophenols greater than monochlorophenols. |
2(0,0,0,2) | Details |
| 13129501 | Ishihara A, Nishiyama N, Sugiyama S, Yamauchi K: The effect of endocrine disrupting chemicals on thyroid hormone binding to Japanese quail transthyretin and thyroid hormone receptor. Gen Comp Endocrinol. 2003 Oct 15;134(1):36-43. Diethylstilbestrol, ioxynil (IC50 =1.1+/-0.5 nM) and pentachlorophenol (IC50 = 6.3+/-3.8 nM) displaced [125I] T3 from qTTR more effectively than unlabeled T3 (IC50 = 9.7+/-0.9 nM) did. |
2(0,0,0,2) | Details |
| 17553549 | Morgado I, Hamers T, Van der Ven L, Power DM: Disruption of thyroid hormone binding to sea bream recombinant transthyretin by ioxinyl and polybrominated diphenyl ethers. Chemosphere. 2007 Aug;69(1):155-63. Epub 2007 Jun 5. |
2(0,0,0,2) | Details |
| 18243807 | Eguchi R, Ishihara A, Yamauchi K: Interaction of diethylstilbestrol and ioxynil with transthyretin in chicken serum. Comp Biochem Physiol C Toxicol Pharmacol. 2008 Apr;147(3):345-50. Epub 2008 Jan 12. The association of suspected endocrine-disrupting chemicals (EDCs), diethylstilbestrol (DES), ioxynil and pentachlorophenol (PCP), with chicken serum proteins was investigated in relation to thyroid system disruption. |
2(0,0,0,2) | Details |
| 18441837 | Suzuki G, Takigami H, Watanabe M, Takahashi S, Nose K, Asari M, Sakai S: Identification of brominated and chlorinated phenols as potential thyroid-disrupting compounds in indoor dusts. Environ Sci Technol. 2008 Mar 1;42(5):1794-800. Our previous study demonstrated that compounds in indoor dusts strongly inhibit (T4) binding to the human thyroid hormone transport protein transthyretin (TTR) in vitro. Here, we used chemical fractionation with in vitro competitive human TTR-binding assay and GC-MS to analyze the TTR-binding compounds in a sulfuric-acid-treated dust extract. 2,4,6-Tribromophenol (TriBPh) and 2,3,4,5,6-pentachlorophenol (PeCPh) were potent TTR-binding compounds in all dust samples. 2,4,6-TriBPh- and 2,3,4,5,6-PeCPh-derived theoretical T4 equivalents (T4EQs), calculated arithmetically from the concentrations and relative potencies, accounted for about 40-70% of experimental T4EQs detected in indoor dusts, indicating that these compounds contributed strongly to the TTR-binding potency of indoor dust. |
1(0,0,0,1) | Details |