Protein Information

Name alpha tubulin
Synonyms Alpha tubulin ubiquitous; Tubulin K alpha 1; Tubulin alpha ubiquitous chain; K alpha 1; K ALPHA 1 protein; alpha tubulin; K alpha 1s; K ALPHA 1 proteins…

Compound Information

Name carbendazim
CAS

Reference List

PubMed Abstract RScore(About this table)
11369590 Correa LM, Miller MG: Microtubule depolymerization in rat seminiferous epithelium is associated with diminished tyrosination of alpha-tubulin. Biol Reprod. 2001 Jun;64(6):1644-52.

Tyrosinated alpha-tubulin (52 kDa) was localized in both tubulin pools and had decreased tyrosination in the microtubule pool after carbendazim treatment.
14(0,0,2,4) Details
15989278 Chen CJ, Li J, Qi ZQ, Wang JX, Zhou MG: [Cloning of alpha-tubulin gene from Fusarium graminearum and analyzing its relationship with carbendazim-resistance]. Wei Sheng Wu Xue Bao. 2005 Apr;45(2):288-91.
13(0,0,2,3) Details
15870464 Sampson K, Heath IB: The dynamic behaviour of microtubules and their contributions to hyphal tip growth in Aspergillus nidulans. Microbiology. 2005 May;151(Pt 5):1543-55.

Reduced MTs in the tip, during mitosis or after exposure to the MT inhibitor carbendazim (MBC), generally correlated with reduced, but continuing growth and near-normal tip morphology.
To address this issue, MT dynamics and subunit distribution were analysed in a strain of Aspergillus nidulans expressing GFP-alpha-tubulin.
1(0,0,0,1) Details
17107551 Zou G, Ying SH, Shen ZC, Feng MG: Multi-sited mutations of beta-tubulin are involved in benzimidazole resistance and thermotolerance of fungal biocontrol agent Beauveria bassiana. Environ Microbiol. 2006 Dec;8(12):2096-105.

All mutations restricted to the half of beta-tubulin close to alpha-tubulin were likely involved in variation in each of the traits concerned but their interactions were complicated.
Among 20 wild strains of Beauveria bassiana (a well-known fungal biocontrol agent) tested in this study, 19 were sensitive or highly sensitive to carbendazim (methyl 2-benzimidazole carbamate), a typical benzimidazole fungicide, despite low resistance found in one strain.
1(0,0,0,1) Details
12215672 Correa LM, Nakai M, Strandgaard CS, Hess RA, Miller MG: Microtubules of the mouse testis exhibit differential sensitivity to the microtubule disruptors Carbendazim and colchicine. Toxicol Sci. 2002 Sep;69(1):175-82.

0(0,0,0,0) Details