Protein Information

Name Potassium channel (protein family or complex)
Synonyms Potassium channel

Compound Information

Name diphenylamine
CAS

Reference List

PubMed Abstract RScore(About this table)
11023649 Souza MM, Boyle RT, Lieberman M: Different physiological mechanisms control isovolumetric regulation and regulatory volume decrease in chick embryo cardiomyocytes. Cell Biol Int. 2000;24(10):713-21.

Potassium channel blockers, quinidine and Ba (2+), and the chloride channel blocker, diphenylamine-2-carboxylate (DPC), compromise IVR in our model.
31(0,1,1,1) Details
8801205 Lomax RB, Warhurst G, Sandle GI: Characteristics of two basolateral potassium channel populations in human colonic crypts. Gut. 1996 Feb;38(2):243-7.

High conductance (138 pS) K+ channels were seen in 25% of patches (one or two channels per patch), and significantly inhibited by the addition of 5 mM Ba2+, 1 mM quinidine or 20 mM tetraethylammonium chloride (TEA) to the cytosolic side of excised inside-out patches, whereas 1 mM diphenylamine-2-carboxylic acid (DPC) had no effect.
1(0,0,0,1) Details
9706740 Reddix RA, Mullet D, Fertel R, Cooke HJ: Endogenous nitric oxide inhibits endothelin-1-induced chloride secretion in guinea pig colon. Nitric Oxide. 1998;2(1):28-36.


The reduction in Isc in response to hemoglobin was reversed by L-arginine and blockers of chloride secretion, including bumetanide and diphenylamine-2-carboxylic acid, but not by the potassium channel blockers, barium and tetraethylammonium, nor by amiloride, an epithelial sodium channel blocker.
0(0,0,0,0) Details
10368184 Leonhardt N, Vavasseur A, Forestier C: ATP binding cassette modulators control abscisic acid-regulated slow anion channels in guard cells . Plant Cell. 1999 Jun;11(6):1141-52.

Potent CFTR inhibitors, such as glibenclamide and diphenylamine-2-carboxylic acid, triggered stomatal opening in darkness.
Potassium channel openers, which bind to and act through the sulfonylurea receptor in animal cells, completely suppressed the stomatal opening induced by glibenclamide and recovered the glibenclamide-inhibited slow anion current.
1(0,0,0,1) Details
9815050 Goyal RK, He XD: Evidence for NO. redox form of nitric oxide as nitrergic inhibitory neurotransmitter in gut. Am J Physiol. 1998 Nov;275(5 Pt 1):G1185-92.


We examined the effects of soluble guanylate cyclase inhibitors LY-83583 and 1H-[1,2,4] oxadiazolo [4,3-a] quinoxalin-1-one (ODQ), potassium-channel blockers and putative chloride-channel blockers diphenylamine-2-carboxylate (DPC) and niflumic acid (NFA) on the hyperpolarization elicited by an NO. donor, diethylenetriamine/NO adduct (DNO), NO in solution, and an NO+ donor, sodium nitroprusside (SNP), in the guinea pig ileal circular muscle.
0(0,0,0,0) Details