| Name | phosphodiesterase |
|---|---|
| Synonyms | CAMP specific phosphodiesterase variant PDE4A 10; CAMP specific phosphodiesterase variant TM3; CAMP specific phosphodiesterase; Cyclic AMP phosphodiesterase PDE4A11; Cyclic AMP specific phosphodiesterase HSPDE4A10; DPDE 2; DPDE2; PDE 4… |
| Name | diphenylamine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16593485 | Sanhueza S, Eisenberg S: Cleavage of single-stranded DNA by the varphiX174 A protein: The A-single-stranded DNA covalent linkage. Proc Natl Acad Sci U S A. 1984 Jul;81(14):4285-4289. Incubation of the tryptic digest with snake venom phosphodiesterase gave (32) P-labeled products that migrated on electrophoresis on cellulose plates to the cathode, indicating covalent linkage of (32) P-labeled dAMP residues to a tryptic peptide. /diphenylamine depurination (Burton reaction) of the [alpha-(32) P] -labeled peptide-oligonucleotide complexes caused a transfer of the labeled from dAMP to the peptide. |
2(0,0,0,2) | Details |
| 9546734 | Fong SK, Chan HC: Regulation of anion secretion by in the mouse endometrial epithelium. Biol Reprod. 1998 Apr;58(4):1020-5. Pretreatment with diphenylamine 2,2'-dicarboxylic acid, a Cl- channel blocker, significantly reduced both -induced ISC responses, while pretreatment with amiloride, a Na+ channel blocker, did not exert any effect. Forskolin, an adenylate cyclase activator, and 3-isobutyl-dihydro--1-methyl- a cAMP phosphodiesterase inhibitor, mimicked the ISC response to while MDL12330A, an adenylate cyclase inhibitor, completely abolished the PGE2-induced ISC. |
1(0,0,0,1) | Details |
| 6087521 | Walter RD, Albiez EJ: Interaction of amoscanate with the -phosphodiesterases from Schistosoma mansoni, Onchocerca volvulus and bovine heart. Tropenmed Parasitol. 1984 Jun;35(2):78-80. It is proposed that the inhibition of -phosphodiesterase-activity by amoscanate and derivatives - resulting in accumulation of - might subsequently lead to disturbances in the regulation of metabolic areas like glycogen metabolism which are controlled by -dependent protein kinases. |
1(0,0,0,1) | Details |
| 10967407 | Jafari M, Rabbani A: Dose and time dependent effects of on release, cell survival and DNA fragmentation of alveolar macrophages from rat lung. Toxicology. 2000 Aug 21;149(2-3):101-8. In this study, the effect of two concentration ranges of the cAMP phosphodiesterase inhibitor, on alveolar macrophage function was investigated by measuring survival rate, production and DNA fragmentation. However, at higher concentrations (5-20 mM), at which the viability was higher than the control, a significant increase in both production and DNA degradation, as judged by agarose gel and diphenylamine reaction, was obtained for 3 and 24 h of culture. |
1(0,0,0,1) | Details |
| 8889957 | Brzuszczak IM, Zhao J, Bell C, Stiel D, Fielding I, Percy J, Smith R, O'Loughlin EV: Cyclic AMP-dependent anion secretion in human small and large intestine. . J Gastroenterol Hepatol. 1996 Sep;11(9):804-10. Addition of the phosphodiesterase inhibitor IBMX induced an increase in the short-circuit current (Isc) equivalent to the net increase in Cl- secretion. The Isc was inhibited by diphenylamine decarboxylate (DPC; Cl- channel blocker), bumetanide (basolateral Na+/K+/2Cl- cotransporter), BaCl2 (basolateral K+ channel) and Cl- free buffer in both segments and indomethacin (cyclo-oxygenase inhibitor) in colon alone. |
1(0,0,0,1) | Details |
| 2821159 | Reuss L: Cyclic AMP inhibits Cl-/HCO3- exchange at the apical membrane of Necturus gallbladder epithelium. J Gen Physiol. 1987 Aug;90(2):173-96. Intracellular cAMP levels were raised by addition of either the phosphodiesterase inhibitor (3 X 10 (-3) M) or the adenylate cyclase activator forskolin (10 (-5) M) to the serosal bathing solution. Estimates of the conductive flux, obtained by either reducing simultaneously mucosal [Cl-] and [HCO3-] or lowering [Cl-] alone in the presence of a blocker of anion exchange (diphenylamine-2-carboxylate), indicate that elevation of intracellular cAMP inhibited the anion exchanger by approximately 50%. |
1(0,0,0,1) | Details |
| 3112408 | Bjerregaard HF, Nielsen R: -stimulated glandular ion and water secretion in isolated frog skin (Rana esculenta). J Membr Biol. 1987;97(1):9-19. The -stimulated Cl secretion could be inhibited by the presence of ouabain or in the basolateral solution or diphenylamine-2-carboxylate in the apical solution. The -stimulated Cl secretion was enhanced by the phosphodiesterase inhibitor, indicating that the effect of was caused by an increase in the intracellular cAMP level in the gland cells. |
1(0,0,0,1) | Details |
| 1719981 | Chao AC, Katayama Y: Regulation of endogenous conductance in Xenopus oocytes. Biochem Biophys Res Commun. 1991 Nov 14;180(3):1377-82. Thus, radiotracer efflux measurement appears to be a sensitive assay method to study stimulus-secretion coupling in oocytes. 125I efflux was suppressed by the C1- channel blocker diphenylamine-2-carboxylate, but was insensitive to bumetanide. |
0(0,0,0,0) | Details |
| 15135328 | Nakahara T, Mitani A, Saito M, Sakamoto K, Ishii K: Diphenylamine-2-carboxylic acid potentiates the cyclic nucleotides-mediated relaxation of porcine coronary artery: possible involvement of the inhibitory effect on the efflux of cyclic nucleotides. Vascul Pharmacol. 2004 Feb;41(1):21-5. |
0(0,0,0,0) | Details |