Protein Information

Name angiotensin II
Synonyms AGT; ANG II; ANHU; Angiotensin I; Angiotensin II; Angiotensinogen; Angiotensinogen precursor; SERPINA 8…

Compound Information

Name diphenylamine
CAS

Reference List

PubMed Abstract RScore(About this table)
7932649 Bescond J, Bois P, Petit-Jacques J, Lenfant J: Characterization of an angiotensin-II-activated chloride current in rabbit sino-atrial cells. J Membr Biol. 1994 Jun;140(2):153-61.

Anthracene-9-carboxylic acid and diphenylamine-2-carboxylic acid (chloride channels blockers) were found to be effective in blocking the AII-sensitive current.
3(0,0,0,3) Details
1443868 Tamaoki J, Isono K, Chiyotani A, Kondo M, Konno K: Angiotensin II-1 receptor-mediated Cl secretion by canine tracheal epithelium. Am Rev Respir Dis. 1992 Nov;146(5 Pt 1):1187-91.

Diphenylamine-2-carboxylate, Cl-free medium, indomethacin, the phospholipase A2 inhibitor mepacrine, and the methyltransferase inhibitor 3-deazaadenosine reduced the change in ISC, whereas amiloride and the lipoxygenase inhibitor AA-861 did not.
2(0,0,0,2) Details
3828657 Cox HM, Cuthbert AW, Munday KA: The effect of angiotensin II upon electrogenic ion transport in rat intestinal epithelia. Br J Pharmacol. 1987 Feb;90(2):393-401.

AII responses were totally inhibited by the chloride channel blocker, diphenylamine-2-carboxylate (DPC) while cotransport inhibitors e.g. piretanide and frusemide significantly reduced the size of AII responses in colon and jejunum.
2(0,0,0,2) Details
1425983 Tamaoki J, Chiyotani A, Takeyama K, Konno K: Effects of angiotensin II and angiotensin III on airway epithelial short-circuit current: involvement of pertussis toxin-sensitive G protein. Eur J Pharmacol. 1992 Sep 10;220(1):87-90.

Both peptides increased the short-circuit current (Isc), an effect that was accompanied by the release of prostaglandin (PG) E2 and was abolished by indomethacin and diphenylamine-2-carboxylate but not by amiloride.
2(0,0,0,2) Details
2165124 Wong PY, Fu WO, Huang SJ, Law WK: Effect of angiotensins on electrogenic anion transport in monolayer cultures of rat epididymis. J Endocrinol. 1990 Jun;125(3):449-56.

Confluent monolayers cultured from the rat cauda epididymidis have been shown to respond to angiotensin I (AI) and angiotensin II (AII) when studied under short-circuit conditions and bathed on both sides with Krebs-Henseleit solution.
The increase in SCC by AII was dependent upon extracellular Cl- and was inhibited by addition of a Cl- channel blocker, diphenylamine 2-carboxylate, to the apical surface.
1(0,0,0,1) Details
16081479 Robert R, Norez C, Becq F: Disruption of CFTR chloride channel alters mechanical properties and cAMP-dependent Cl- transport of mouse aortic smooth muscle cells. J Physiol. 2005 Oct 15;568(Pt 2):483-95. Epub 2005 Aug 4.


Angiotensin II and the calcium ionophore A23187 stimulated Ca (2)(+)-dependent Cl (-) channels in VSMCs from both genotypes.
1(0,0,0,1) Details
1319450 Leung AY, Leung PY, Cheng-Chew SB, Wong PY: The role of calcitonin gene-related peptide in the regulation of anion secretion by the rat and human epididymis. J Endocrinol. 1992 May;133(2):259-68.

The current could be inhibited by apical application of the chloride channel blocker, diphenylamine-2-carboxylate.
In contrast to bradykinin, angiotensin II and endothelin I, the effect of CGRP was independent of prostaglandin synthesis.
1(0,0,0,1) Details