| Name | Substance P |
|---|---|
| Synonyms | Hs.2563; PPT; NK2; NKA; NKNA; Neurokinin 1; Neurokinin 2; Neurokinin A… |
| Name | diphenylamine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11504691 | Trout L, Corboz MR, Ballard ST: Mechanism of substance P-induced liquid secretion across bronchial epithelium. Am J Physiol Lung Cell Mol Physiol. 2001 Sep;281(3):L639-45. The anion channel blockers diphenylamine-2-carboxylate (DPC) and 5-nitro-2-(3-phenylpropylamino) (NPPB) inhibited > 90% of substance P-induced liquid secretion, whereas DIDS had no effect. |
4(0,0,0,4) | Details |
| 1375640 | Sun XP, Supplisson S, Torres R, Sachs G, Mayer E: Characterization of large-conductance channels in rabbit colonic smooth muscle. J Physiol. 1992 Mar;448:355-82. The stilbene derivative diiso-thiocyanato-stilbene-disulphonic acid (DIDS) and the diphenylamine-2-carboxylate analogue 5-nitro-2-(3-phenylpropylamino)- (NPPB) caused a dose-dependent, reversible flicker block of the small conductance and significantly reduced the macroscopic current flow through the channel. 6. In addition, the regulation of these channels by neurokinin-1 (NK-1) receptor agonists and G proteins was studied. 2. |
2(0,0,0,2) | Details |
| 1718908 | Tamaoki J, Sakai N, Isono K, Kanemura T, Chiyotani A, Yamauchi F, Takizawa T, Konno K: Effect of neutral endopeptidase inhibition on substance-P-induced increase in short-circuit current of canine cultured tracheal epithelium. Int Arch Allergy Appl Immunol. 1991;95(2-3):169-73. This stimulatory effect of submucosal SP was abolished by diphenylamine-2-carboxylate and Cl-free medium, but not by amiloride. |
2(0,0,0,2) | Details |
| 8232596 | Cox HM, Tough IR, Grayson K, Yarrow S: Pharmacological characterisation of neurokinin receptors mediating anion secretion in rat descending colon mucosa. Naunyn Schmiedebergs Arch Pharmacol. 1993 Aug;348(2):172-7. Substance P (SP), neurokinin A (NKA), neurokinin B (NKB), [Sar9, Met (O2) 11]-SP (SMSP), senktide, [beta Ala8]-NKA (4-10) and neuropeptide gamma (NP gamma) all stimulate secretory responses in rat descending colon mucosa under voltage clamp conditions. |
1(0,0,0,1) | Details |
| 11159013 | Fortner CN, Lorenz JN, Paul RJ: Chloride channel function is linked to epithelium-dependent airway relaxation. Am J Physiol Lung Cell Mol Physiol. 2001 Feb;280(2):L334-41. We previously reported that substance P (SP) and ATP evoke transient, epithelium-dependent relaxation of mouse tracheal smooth muscle. In perfused mouse tracheas, the responses to SP and ATP were both inhibited by the Cl- channel inhibitors diphenylamine-2-carboxylate and 5-nitro-2-(3-phenylpropylamino) |
1(0,0,0,1) | Details |
| 9711352 | Lobasso S, Lippe C, Bellantuono V, Ardizzone C: Action of physalaemin on the ionic transport across the frog skin. . Arch Physiol Biochem. 1998 Aug;105(4):329-36. Furthermore diphenylamine-2-carboxylic acid (DPC, 0.1 mM in the external fluid), an inhibitor of Cl- channels, decreased the effect of the peptide on SCC by 48%. |
0(0,0,0,0) | Details |