| Name | lactate dehydrogenase (protein family or complex) |
|---|---|
| Synonyms | LDH; lactate dehydrogenase; lactate dehydrogenases |
| Name | diphenylamine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 6863915 | Verhoef J, Sharma SD: Inhibition of human natural killer activity by lysosomotropic agents. J Immunol. 1983 Jul;131(1):125-31. Dansylcadaverine (DCA), diphenylamine (DPA), and lidocaine (LID) inhibited NK activity of nylon wool-purified and large granular lymphocyte (LGL)-enriched cell preparations. All three amines that inhibited NK activity also reduced the intracellular concentration of the lysosomal enzyme beta-glucuronidase without affecting the activity of the cytoplasmic enzyme lactate dehydrogenase. |
1(0,0,0,1) | Details |
| 10644658 | Meng X, Reeves WB: Effects of chloride channel inhibitors on H (2) O (2)-induced renal epithelial cell injury. Am J Physiol Renal Physiol. 2000 Jan;278(1):F83-90. Exposure of LLC-PK (1) cells to 1 mM H (2) O (2) resulted in the following: depletion of intracellular ATP content; DNA damage; lipid peroxidation; and a loss of membrane integrity to both small molecules, e.g., trypan blue, and macromolecules, e.g., lactate dehydrogenase (LDH), and cell death. Substitution of Cl (-) by or the inclusion of certain Cl (-) channel blockers, e.g., diphenylamine-2-carboxylate (DPC), 5-nitro-2-(3-phenylpropylamino). (NPPB), and niflumic acid, prevented the H (2) O (2)-induced loss of membrane integrity to LDH. |
1(0,0,0,1) | Details |
| 9765339 | Masubuchi Y, Saito H, Horie T: Structural requirements for the hepatotoxicity of nonsteroidal anti-inflammatory drugs in isolated rat hepatocytes. J Pharmacol Exp Ther. 1998 Oct;287(1):208-13. We investigated the cytotoxicity of 18 acidic NSAIDs (3 salicylic acids, 3 anthranilic acids, 6 arylacetic acids, 6 arylpropionic acids) to freshly isolated rat hepatocytes as assessed by the NSAID-induced leakage of lactate dehydrogenase (LDH) in order to determine structural requirements for the direct hepatotoxicity of the NSAIDs. Because the cytotoxic NSAIDs were of two types as classified by their "skeleton," diphenyl and diphenylamine, we tested the cytotoxicity of the compounds. |
1(0,0,0,1) | Details |
| 6309593 | McQueen CA, Williams GM: Cytotoxicity of xenobiotics in adult rat hepatocytes in primary culture. Fundam Appl Toxicol. 1982 May-Jun;2(3):139-44. The leakage of two intracellular enzymes, lactate dehydrogenase (LDH) and glutamic oxaloacetic transaminase (GOT) were compared as indicators of cell damage. |
1(0,0,0,1) | Details |
| 10391492 | Queiroz G, Meyer DK, Meyer A, Starke K, von Kugelgen I: A study of the mechanism of the release of ATP from rat cortical astroglial cells evoked by activation of glutamate receptors. Neuroscience. 1999;91(3):1171-81. Of several compounds tested as potential blockers of ATP transporters or channels only glibenclamide (100 microM) and diphenylamine-2-carboxylate (500 microM), which block the cystic fibrosis transmembrane conductance regulator, caused any change: both reduced the effect of AMPA without changing the effects of and (only glibenclamide tested) kainate. |
0(0,0,0,0) | Details |
| 9843914 | Schulze-Lohoff E, Hugo C, Rost S, Arnold S, Gruber A, Brune B, Sterzel RB: Extracellular ATP causes apoptosis and necrosis of cultured mesangial cells via P2Z/P2X7 receptors. Am J Physiol. 1998 Dec;275(6 Pt 2):F962-71. Apoptotic DNA fragmentation was confirmed by the diphenylamine assay and by staining with the DNA-specific fluorochrome Hoechst 33258. |
0(0,0,0,0) | Details |
| 1754348 | Korovina NA, Levitskaia SV, Reshetniak GP, Iur'eva EA, Pykov MI: [Differential diagnosis of gallbladder diseases in children] . Pediatriia. 1991;(9):41-5. The duodenal contents was explored by microscopy of the sediment and biochemistry which included analysis in the vesicular and liver portions of the concentrations of phospholipids, activity of phospholipases A and C as well as measurements of kinase, lactate dehydrogenase, alkaline phosphatase, C-reactive protein and of the diphenylamine index. |
31(0,1,1,1) | Details |