| Name | ClC 2 |
|---|---|
| Synonyms | CIC 2; Clc2; CIC2; CLCN 2; CLCN2; Chloride channel 2; Chloride channel protein 2; ClC 2… |
| Name | diphenylamine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9486141 | Furukawa T, Ogura T, Katayama Y, Hiraoka M: Characteristics of rabbit ClC-2 current expressed in Xenopus oocytes and its contribution to volume regulation. Am J Physiol. 1998 Feb;274(2 Pt 1):C500-12. ClC-2 currents were inhibited by 5-nitro-2-(3-phenylpropylamino) (NPPB), diphenylamine-2-carboxylic acid (DPC), and anthracene-9-carboxylic acid (9-AC), with a potency order of NPPB > DPC = 9-AC, but were resistant to stilbene disulfonates. |
88(1,1,1,8) | Details |
| 7838687 | Komwatana P, Dinudom A, Young JA, Cook DI: Characterization of the Cl- conductance in the granular duct cells of mouse mandibular glands. Pflugers Arch. 1994 Oct;428(5-6):641-7. Finally, we show that the conductance is not blocked by the addition of any of the following compounds to the extracellular solution: anthracene-9-carboxylate (A9C, 1 mmol/l), diphenylamine-2-carboxylate (DPC, 1 mmol/l), 5-nitro-2-(3-phenylpropylamino)- (NPPB, 100 mumol/l), 4,4'-diisothiocyanato-stilbene-2,2'-disulphonate (DIDS, 100 mumol/l), indanyloxyacetic acid (IAA-94, 100 mumol/l), (100 mumol/l), glibenclamide (100 mumol/l) and Ba2+ (5 mmol/l). The properties of the ductal Cl- conductance most nearly resemble those of the ClC-2 channel. |
2(0,0,0,2) | Details |
| 7539220 | Dinudom A, Komwatana P, Young JA, Cook DI: A forskolin-activated Cl- current in mouse mandibular duct cells. Am J Physiol. 1995 May;268(5 Pt 1):G806-12. We have previously shown that unstimulated granular duct cells of mouse mandibular gland contain a hyperpolarization-activated Cl- conductance with characteristics resembling the hyperpolarization-activated volume-sensitive Cl- channel (ClC-2). The current carried by this conductance is attenuated 65% by 1 mmol/l diphenylamine-2-carboxylate but is not affected by 0.1 mmol/l4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid or 0.1 mmol/l glibenclamide. |
1(0,0,0,1) | Details |
| 8745282 | Fritsch J, Edelman A: Modulation of the hyperpolarization-activated Cl- current in human intestinal T84 epithelial cells by phosphorylation. J Physiol. 1996 Jan 1;490 ( Pt 1):115-28. ICl,hyp was partially inhibited by 1 mM diphenylamine-2-carboxylic acid or 0.1 mM 5-nitro-2-(3-phenylpropylamino)- and was completely blocked by Cd2+ (> 300 microM). We conclude that hyperpolarization-activated Cl- channels similar to those of ClC-2 channels (mammalian homologue of Torpedo chloride channel ClC-0) are present in T84 cells, and that their gating properties are modulated by phosphorylation. |
1(0,0,0,1) | Details |