Protein Information

Name hemoglobin (protein family or complex)
Synonyms Hemoglobin; Hemoglobins

Compound Information

Name diphenylamine
CAS

Reference List

PubMed Abstract RScore(About this table)
9706740 Reddix RA, Mullet D, Fertel R, Cooke HJ: Endogenous nitric oxide inhibits endothelin-1-induced chloride secretion in guinea pig colon. Nitric Oxide. 1998;2(1):28-36.

During neural blockade with tetrodotoxin, the nitric oxide scavenger, hemoglobin, and the nitric oxide synthase inhibitor, N omega-nitro-L-arginine (L-NNA), reduced Isc.
The reduction in Isc in response to hemoglobin was reversed by L-arginine and blockers of chloride secretion, including bumetanide and diphenylamine-2-carboxylic acid, but not by the potassium channel blockers, barium and tetraethylammonium, nor by amiloride, an epithelial sodium channel blocker.
2(0,0,0,2) Details
6743655 Sullivan SG, Stern A: Membrane protein changes induced by tert-butyl hydroperoxide in red blood cells. Biochim Biophys Acta. 1984 Jul 25;774(2):215-20.

Membrane glycoproteins were unaffected. t-Butyl hydroperoxide increased hemoglobin binding to ghosts.
Butylated hydroxytoluene, diphenylamine and ascorbate, compounds that inhibit t-butyl hydroperoxide-induced red cell membrane lipid peroxidation, had no effect on t-butyl hydroperoxide-induced membrane protein changes.
2(0,0,0,2) Details
326025 Ferretti JJ, Lu W, Liu MB: Mutagenicity of benzidine and related compounds employed in the detection of hemoglobin. Am J Clin Pathol. 1977 Jun;67(6):526-7.

Four compounds tested with this system, o-anisidine, diphenylamine, guaicol, and o-toluidine, were not mutagenic.
2(0,0,0,2) Details
12778203 : Carcinogenesis Bioassay of 2-Biphenylamine Hydrochloride (CAS No. 2185-92-4) in F344/N Rats and B6C3F1 Mice (Feed Study). Natl Toxicol Program Tech Rep Ser. 1982 Oct;233:1-159.

The technical-grade 2-biphenylamine caused a dose-related decrease in hemoglobin concentration and a dose-related increase in leukocyte count in male and female mice in the 13-week study.
It is present as a contaminant in 4-biphenylamine (a rubber antioxidant) and in diphenylamine (a dye intermediate, stabilizer for nitrocellulose explosives, and a topical agent for prevention of screwworm infestation in animals).
1(0,0,0,1) Details