Protein Information

Name pituitary adenylate cyclase activating polypeptide
Synonyms ADCYAP 1; ADCYAP1; Adenylate cyclase activating polypeptide 1; PACAP; PACAP related peptide; PACAP27; PACAP38; PRP48…

Compound Information

Name diphenylamine
CAS

Reference List

PubMed Abstract RScore(About this table)
9379115 Zhou WL, Leung PS, Wong TP, Dun NJ, Wong PY, Chan HC: Local regulation of epididymal anion secretion by pituitary adenylate cyclase-activating polypeptide. J Endocrinol. 1997 Sep;154(3):389-95.

The Isc response to PACAP38 was abolished in Cl-(-) free solution and completely inhibited by the Cl- channel blocker, diphenylamine-dicarboxylic acid.
39(0,1,1,9) Details
11237416 Leung PS, So SC, Lam SY, Tsang LL, Chung YW, Chan HC: Local regulation of anion secretion by pituitary adenylate cyclase-activating polypeptide in human colonic T84 cells. Cell Biol Int. 2001;25(2):123-9.

The I (SC) responses to both PACAP-27 and PACAP-38 were suppressed respectively by the non-selective Cl (-) channel blocker, diphenylamine-dicarboxylic acid (DPC), by the Ca (2+) dependent Cl (-) channel blocker, diisothiocyanatostilbene-disulfonic acid (DIDS) and by the Ca (2+) chelator, BAPTA-AM, indicating the involvement of Ca (2+).
2(0,0,0,2) Details