Protein Information

Name KCNQ1
Synonyms ATFB 1; KCNA 8; KCNA8; ATFB1; IKs producing slow voltage gated potassium channel alpha subunit KvLQT1; IKs producing slow voltage gated potassium channel subunit alpha KvLQT1; JLNS 1; JLNS1…

Compound Information

Name diphenylamine
CAS

Reference List

PubMed Abstract RScore(About this table)
11842001 Ko WH, Law VW, Yip WC, Yue GG, Lau CW, Chen ZY, Huang Y: Stimulation of chloride secretion by baicalein in isolated rat distal colon. Am J Physiol Gastrointest Liver Physiol. 2002 Mar;282(3):G508-18.

The baicalein-induced I (sc) were inhibited by mucosal application of diphenylamine-2-carboxylic acid (100 microM) and glibenclamide (500 microM) and basolateral application of chromanol 293B (30 microM), a blocker of K (v) LQT1 channels and Ba (2+) ions (5 mM).
31(0,1,1,1) Details
12181292 Cowley EA, Linsdell P: Oxidant stress stimulates anion secretion from the human airway epithelial cell line Calu-3: implications for cystic fibrosis lung disease. J Physiol. 2002 Aug 15;543(Pt 1):201-9.

This increase was almost entirely abolished by the addition of diphenylamine-2-carboxylate (DPC), implicating the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel in the response.
Basolateral G (K) was reduced by the K+ channel inhibitors clotrimazole and clofilium, indicating roles for KCNN4 and KCNQ1 in the H2O2-stimulated response.
1(0,0,0,1) Details