| Name | CYP2E1 |
|---|---|
| Synonyms | CPE 1; Flavoprotein linked monooxygenase; Xenobiotic monooxygenase; Microsomal monooxygenase; CPE1; CYP2E; CYP2E1; CYP2E1 protein… |
| Name | allyl alcohol |
|---|---|
| CAS | 2-propen-1-ol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10528996 | Hammond AH, Fry JR: Effect of cyanamide on toxicity and depletion in rat hepatocyte cultures: differences between two dichloropropanol isomers. Chem Biol Interact. 1999 Sep 30;122(2):107-15. Induction of CYP2E1 also potentiated the toxicity of 2,3-dichloropropanol, and in these cultures cyanamide pre-treatment significantly increased both toxicity and depletion. |
2(0,0,0,2) | Details |
| 8194125 | Miguez MP, Anundi I, Sainz-Pardo LA, Lindros KO: Hepatoprotective mechanism of silymarin: no evidence for involvement of cytochrome P450 2E1. Chem Biol Interact. 1994 Apr;91(1):51-63. The involvement of the -inducible cytochrome P450 2E1 in the hepatoprotective mechanism of the plant extract silymarin, and its main active component silybin, was investigated in isolated hepatocytes. Allyl alcohol toxicity, associated lipid peroxidation and GSH depletion was efficiently counteracted by silymarin (0.01-0.5 mM), and at higher concentrations by silybin. |
1(0,0,0,1) | Details |
| 15242186 | Valentova K, Moncion A, de Waziers I, Ulrichova J: The effect of Smallanthus sonchifolius leaf extracts on rat hepatic metabolism. Cell Biol Toxicol. 2004 Mar;20(2):109-20. In this paper, we present the effects of two organic fractions and two aqueous extracts from the leaves of S. sonchifolius on rat hepatocyte viability, on oxidative damage induced by tert-butyl hydroperoxide (t-BH) and allyl alcohol (AA), and on metabolism and their insulin-like effect on the expression of cytochrome P450 (CYP) mRNA. Moreover, the effects of the organic fractions (200 and 250 microg/ml) and to a lesser extent, the tea infusion (500 microg/ml) on rat CYP2B and CYP2E mRNA expression, were comparable to those observed with insulin. |
1(0,0,0,1) | Details |
| 11306107 | Moridani MY, Khan S, Chan T, Teng S, Beard K, O'Brien PJ: Cytochrome P450 2E1 metabolically activates propargyl propiolaldehyde-induced hepatocyte cytotoxicity. Chem Biol Interact. 2001 Jan 30;130-132(1-3):931-42. Propargyl (2-propyn-1-ol), because of its structural similarity to allyl alcohol, was thought to be activated by alcohol dehydrogenase. |
1(0,0,0,1) | Details |
| 14610242 | Sawant SP, Dnyanmote AV, Shankar K, Limaye PB, Latendresse JR, Mehendale HM: Potentiation of carbon tetrachloride hepatotoxicity and lethality in type 2 diabetic rats. J Pharmacol Exp Ther. 2004 Feb;308(2):694-704. Epub 2003 Nov 10. Nonlethal doses of allyl alcohol (35 mg/kg i.p.), CCl (4) (2 ml/kg i.p.), or thioacetamide (300 mg/kg i.p.) yielded 80 to 100% mortality in diabetic rats. |
0(0,0,0,0) | Details |
| 10547960 | Wang RS, Nakajima T, Honma T: Different change patterns of the isozymes of cytochrome P450 and glutathione S-transferases in chemically induced liver damage in rat. Ind Health. 1999 Oct;37(4):440-8. Rats were administered 1,1-dichloroethylene (DCE), allyl alcohol (AA), bromobenzene (BB) and N,N-dimethylformamide (DMF) p.o. once every two days for 7 times, and decapitated 18 hr after the last administration. |
0(0,0,0,0) | Details |
| 11515535 | Yang JW, Shin JS, Lee JJ, Chang HI, Kim CW: In vitro model using mouse hepatocytes for study of stress. Biosci Biotechnol Biochem. 2001 Jul;65(7):1528-33. These results on CYP2E1 induction demonstrate that primary mouse hepatocytes, when using and allyl alcohol as substrates and in insulin-free medium, provide a suitable system for the studies of the role of CYP2E1 in xenobiotic metabolism and toxicity. |
89(1,1,2,4) | Details |
| 8861782 | Khan S, Sood C, O'Brien PJ: The involvement of cytochrome P4502E1 in 2-bromoethanol-induced hepatocyte cytotoxicity. Pharmacol Toxicol. 1996 Apr;78(4):241-8. However, cytochrome P4502E1 (CYP2E1) inhibitors/substrates were more effective at preventing 2-bromoethanol-induced GSH depletion, lipid peroxidation and cytotoxicity suggesting that 2-bromoethanol is mostly metabolically activated by CYP2E1. |
4(0,0,0,4) | Details |