| Name | aldehyde dehydrogenase (protein family or complex) |
|---|---|
| Synonyms | aldehyde dehydrogenase; aldehyde dehydrogenases |
| Name | allyl alcohol |
|---|---|
| CAS | 2-propen-1-ol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2886311 | Rikans LE: The oxidation of acrolein by rat liver aldehyde dehydrogenases. Drug Metab Dispos. 1987 May-Jun;15(3):356-62. The effect of aldehyde dehydrogenase inhibition on allyl alcohol toxicity was determined by pretreating rats with cyanamide or disulfiram prior to treatment with allyl alcohol. |
197(2,3,3,7) | Details |
| 3889625 | Neudecker T, Henschler D: is mutagenic in Salmonella typhimurium. Mutat Res. 1985 Apr-May;156(1-2):33-7. Another metabolic pathway, namely hydrolysis to allyl alcohol and oxidation to acrolein, a known mutagen, also seems possible as cyanamide, inhibitor of aldehyde dehydrogenase, can slightly increase the mutagenic potential. |
81(1,1,1,1) | Details |
| 9972923 | Lee JY, Chung SM, Lee MY, Chung JH: co-exposure increases lethality of allyl alcohol in male Sprague-Dawley rats. J Toxicol Environ Health A. 1999 Jan 22;56(2):121-30. Since allyl alcohol and are both metabolized by alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), could affect allyl-alcohol induced toxicity under in vivo coexposure conditions. |
81(1,1,1,1) | Details |
| 3156001 | Ohno Y, Jones TW, Ormstad K: Allyl alcohol toxicity in isolated renal epithelial cells: protective effects of low molecular weight thiols. Chem Biol Interact. 1985 Jan;52(3):289-99. Pyrazole, an inhibitor of alcohol dehydrogenase, abolished the cytotoxic effects of allyl alcohol whereas inhibition of aldehyde dehydrogenase by disulfiram treatment was found to increase the sensitivity of renal cells to the effects of allyl alcohol. |
81(1,1,1,1) | Details |
| 2596853 | Silva JM, O'Brien PJ: Allyl alcohol- and acrolein-induced toxicity in isolated rat hepatocytes. . Arch Biochem Biophys. 1989 Dec;275(2):551-8. However, cytotoxicity of both allyl alcohol and acrolein was enhanced by the aldehyde dehydrogenase inhibitors cyanamide and disulfiram. |
31(0,1,1,1) | Details |
| 3668850 | Rikans LE, Moore DR: Effect of age and sex on allyl alcohol hepatotoxicity in rats: role of liver and aldehyde dehydrogenase activities. J Pharmacol Exp Ther. 1987 Oct;243(1):20-6. |
6(0,0,1,1) | Details |
| 2795457 | Mitchell DY, Petersen DR: Metabolism of the -acrolein adduct, S-(2-aldehydo-ethyl) by rat liver and aldehyde dehydrogenase. J Pharmacol Exp Ther. 1989 Oct;251(1):193-8. Collectively, these results indicate that the -acrolein adduct formed after exposure to acrolein, or as a result of allyl alcohol oxidation and cyclophosphamide metabolism, can be oxidized by hepatic ALDH or ADH, respectively. |
2(0,0,0,2) | Details |
| 10528996 | Hammond AH, Fry JR: Effect of cyanamide on toxicity and depletion in rat hepatocyte cultures: differences between two dichloropropanol isomers. Chem Biol Interact. 1999 Sep 30;122(2):107-15. The effect of aldehyde dehydrogenase inhibition by cyanamide pre-treatment in vitro on dichloropropanol-dependent toxicity and depletion was investigated in 24 h rat hepatocyte cultures. |
2(0,0,0,2) | Details |
| 11835630 | Burcham PC, Fontaine F: Extensive protein carbonylation precedes acrolein-mediated cell death in mouse hepatocytes. J Biochem Mol Toxicol. 2001;15(6):309-16. Allyl alcohol hepatotoxicity is mediated by an alcohol dehydrogenase-derived biotranformation product, acrolein. Conversely, cyanamide, an aldehyde dehydrogenase inhibitor, enhanced cytotoxicity and protein carbonylation. |
1(0,0,0,1) | Details |
| 3801056 | Jaeschke H, Kleinwaechter C, Wendel A: The role of acrolein in allyl alcohol-induced lipid peroxidation and liver cell damage in mice. Biochem Pharmacol. 1987 Jan 1;36(1):51-7. In vivo-inhibition of alcohol dehydrogenase by pyrazole or induction of aldehyde dehydrogenase by phenobarbital abolished AA-induced liver damage as well as depletion and lipid peroxidation, while inhibition of aldehyde dehydrogenase by cyanamide made a subtoxic dose of AA (0.60 mmol/kg) highly toxic. |
1(0,0,0,1) | Details |
| 8861782 | Khan S, Sood C, O'Brien PJ: The involvement of cytochrome P4502E1 in 2-bromoethanol-induced hepatocyte cytotoxicity. Pharmacol Toxicol. 1996 Apr;78(4):241-8. Furthermore, aldehyde dehydrogenase inhibitors-cyanamide or chloral hydrate increased 2-bromoethanol dependent hepatocyte susceptibility. |
1(0,0,0,1) | Details |
| 2930914 | Ohno Y, Ormstad K, Ross D, Orrenius S: Mechanism of allyl alcohol toxicity and protective effects of low-molecular-weight thiols studied with isolated rat hepatocytes. Toxicol Appl Pharmacol. 1985 Apr;78(2):169-79. The toxicity was prevented by inhibitors of alcohol dehydrogenase and augmented by the aldehyde dehydrogenase inhibitor disulfiram, suggesting that the toxic metabolite was the reactive acrolein. |
1(0,0,0,1) | Details |
| 2886987 | Penttila KE, Makinen J, Lindros KO: Allyl alcohol liver injury: suppression by and relation to transient depletion. Pharmacol Toxicol. 1987 May;60(5):340-4. On the other hand, attempts to potentiate the toxicity of acrolein by the aldehyde dehydrogenase inhibitor cyanamide enhanced only the release of alanine aminotransferase. |
1(0,0,0,1) | Details |