Protein Information

Name glutathione S transferase
Synonyms GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2…

Compound Information

Name allyl alcohol
CAS 2-propen-1-ol

Reference List

PubMed Abstract RScore(About this table)
10547960 Wang RS, Nakajima T, Honma T: Different change patterns of the isozymes of cytochrome P450 and glutathione S-transferases in chemically induced liver damage in rat. Ind Health. 1999 Oct;37(4):440-8.

Rats were administered 1,1-dichloroethylene (DCE), allyl alcohol (AA), bromobenzene (BB) and N,N-dimethylformamide (DMF) p.o. once every two days for 7 times, and decapitated 18 hr after the last administration.
2(0,0,0,2) Details
3377801 Haenen GR, Vermeulen NP, Tai Tin Tsoi JN, Ragetli HM, Timmerman H, Blast A: Activation of the microsomal glutathione-S-transferase and reduction of the glutathione dependent protection against lipid peroxidation by acrolein. Biochem Pharmacol. 1988 May 15;37(10):1933-8.

Allyl alcohol is hepatotoxic.
1(0,0,0,1) Details
6107226 Patel JM, Wood JC, Leibman KC: The biotransformation of allyl alcohol and acrolein in rat liver and lung preparations. Drug Metab Dispos. 1980 Sep-Oct;8(5):305-8.

Epoxides, glycidol, and glycidaldehyde were also found to be substrates for lung and liver cytosolic glutathione S-transferase.
1(0,0,0,1) Details
9212436 Millard PJ, Roth BL, Thi HP, Yue ST, Haugland RP: Development of the FUN-1 family of fluorescent probes for vacuole labeling and viability testing of yeasts. Appl Environ Microbiol. 1997 Jul;63(7):2897-905.

Depletion of cellular thiols, including glutathione, with millimolar concentrations of N-ethylmaleimide, iodoacetamide, or allyl alcohol completely inhibited CIVS production.
Marked reduction in the formation of CIVS by ethacrynic acid and sulfobromophthalein, inhibitors of glutathione S-transferase, suggested that dye processing can involve enzyme-mediated formation of glutathione conjugates.
1(0,0,0,1) Details
2418542 Trela BA, Carlson GP, Chadwick RW, Copeland MF: Comparison of in vivo and in vitro methods for assessing effects of allyl alcohol on the liver. Toxicol Lett. 1985 Dec;29(2-3):77-84.

Naphthol glucuronidation and glutathione-S-transferase activity with 1,2-dichloro-4-nitrobenzene were increased.
1(0,0,0,1) Details