| Name | Acetylcholinesterase |
|---|---|
| Synonyms | ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant… |
| Name | omethoate |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18070496 | Wan WG, Zheng SC, Zou HJ, Ma SD, Tao GZ, Xu ZF, Zhang B, Chen JJ, Fang LY, Zhu ZJ: [Different therapeutic efficacy of parlidoxime PAM-Cl on AChE against acute toxicity of methamidophos, dichlorovs and omethoate]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2007 Oct;25(10):586-9. |
8(0,0,1,3) | Details |
| 17546082 | Chen MH, Han ZJ, Qiao XF, Qu MJ: Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and insecticides. Genome. 2007 Feb;50(2):172-9. Bioassays showed that the resistant strain used was highly or moderately resistant to pirimicarb, omethoate, and monocrotophos (resistance ratio, 263.8, 53.8, and 17.5, respectively), and showed little resistance to deltamethrin or thiodicarb (resistance ratio, 5.2 and 3.4, respectively). |
6(0,0,0,6) | Details |
| 19764241 | Zhao W, Ge PY, Xu JJ, Chen HY: Selective detection of hypertoxic organophosphates pesticides via PDMS composite based acetylcholinesterase-inhibition biosensor. Environ Sci Technol. 2009 Sep 1;43(17):6724-9. Real sample detection was performed and the omethoate residue on Cottomrose Hibiscus leaves was detected with biosensor-1. |
5(0,0,0,5) | Details |
| 18569613 | Rajini PS, Melstrom P, Williams PL: A comparative study on the relationship between various toxicological endpoints in Caenorhabditis elegans exposed to organophosphorus insecticides. J Toxicol Environ Health A. 2008;71(15):1043-50. The toxicity of 10 organophophorus (OP) insecticides-acephate, dimethoate, dichlorvos, dicrotophos, monocrotophos, methamidophos, phosphamidon, omethoate, phosdrin, and trichlorfon-was evaluated in Caenorhabditis elegans using lethality, movement, and acetylcholinesterase (AChE) activity as the endpoints after a 4-hr- exposure period. |
9(0,0,1,4) | Details |
| 19680907 | Chen C, Li Y, Chen M, Chen Z, Qian Y: Organophosphorus pesticide residues in milled rice (Oryza sativa) on the Chinese market and dietary risk assessment. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2009 Mar;26(3):340-7. The present study investigates the occurrence of acetylcholinesterase (AChE)-inhibiting organophosphorus (OP) pesticide residues in milled rice samples obtained form local markets in China during the period 2004-2006 and estimates their cumulative exposure. The results showed that 9.3% of the samples contained detectable residues of at least one of the seven target OP pesticides (chlorpyrifos, dichlorvos, omethoate, methamidophos, parathion-methyl, parathion and triazophos) mainly used for agriculture in China, with concentrations ranging 0.011-1.756 mg kg (-1). |
3(0,0,0,3) | Details |
| 11052723 | Gao JR, Zhu KY: Comparative toxicity of selected organophosphate insecticides against resistant and susceptible clones of the greenbug, Schizaphis graminum (Homoptera: aphididae). J Agric Food Chem. 2000 Oct;48(10):4717-22. The OR-1 clone showed lower levels of resistance to phenyl (parathion and parathion-methyl) and heterocyclic (chlorpyrifos) OPs than to aliphatic OPs (dimethoate, omethoate, disulfoton, and demeton-S-methyl), whereas the OR-2 clone showed a rather broad spectrum of resistance to nearly all OP insecticides examined. In vitro inhibition of acetylcholinesterase (AChE) using six selected OP oxon analogues showed that alterations of AChE were involved in resistance to all OP compounds examined in both the OR-1 and OR-2 clones. |
3(0,0,0,3) | Details |
| 17897769 | Buratti FM, Testai E: Evidences for CYP3A4 autoactivation in the desulfuration of dimethoate by the human liver. Toxicology. 2007 Nov 20;241(1-2):33-46. Epub 2007 Aug 6. It is characterized by low-to-moderate acute mammalian toxicity; similarly to the other OPT pesticides, its mode of action is mediated by the inhibition of acetylcholinesterase (AChE), exerted by its toxic metabolite dimethoate-oxon or omethoate (OME), which is also used as a direct acting pesticide. |
83(1,1,1,3) | Details |
| 15532677 | Benting J, Nauen R: Biochemical evidence that an S431F mutation in acetylcholinesterase-1 of Aphis gossypii mediates resistance to pirimicarb and omethoate. Pest Manag Sci. 2004 Nov;60(11):1051-5. |
82(1,1,1,2) | Details |
| 20106727 | John H, Eddleston M, Clutton RE, Worek F, Thiermann H: Simultaneous quantification of the organophosphorus pesticides dimethoate and omethoate in porcine plasma and urine by LC-ESI-MS/MS and flow-injection-ESI-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jan 14. It also exhibits toxic activity towards mammalian organism provoked by catalytic desulfuration in the liver producing its oxon-derivative omethoate thus inhibiting acetylcholinesterase, initiating cholinergic crisis and ultimately leading to death by respiratory paralysis and cardiovascular collapse. |
81(1,1,1,1) | Details |
| 7316761 | Lotti M, Ferrara SD, Caroldi S, Sinigaglia F: Enzyme studies with human and hen autopsy tissue suggest omethoate does not cause delayed neuropathy in man. Arch Toxicol. 1981 Nov;48(4):265-70. Levels of acetylcholinesterase and neurotoxic esterase were measured in brain autopsy material. |
2(0,0,0,2) | Details |
| 16718740 | Kristensen M, Huang J, Qiao CL, Jespersen JB: Variation of Musca domestica L. acetylcholinesterase in Danish housefly populations. Pest Manag Sci. 2006 Aug;62(8):738-45. Cluster analysis was performed and > 2000 houseflies were assigned to one of three phenotypes based on total acetylcholinesterase activity as well as inhibition by azamethiphos, methomyl or omethoate. |
165(2,2,2,5) | Details |
| 18384757 | Eyer P, Radtke M, Worek F: Reactions of isodimethoate with human red cell acetylcholinesterase. . Biochem Pharmacol. 2008 May 15;75(10):2045-53. Epub 2008 Feb 26. Isodimethoate shows an inhibition rate constant towards human red blood cell acetylcholinesterase (AChE) of 2.3x10 (3) M (-1) min (-1) (pH 7.4, 37 degrees C), indicating a somewhat higher potency than found with omethoate, the CYP450-mediated active metabolite of pure dimethoate. |
41(0,1,2,6) | Details |
| 19894225 | Khajehali J, Van Leeuwen T, Grispou M, Morou E, Alout H, Weill M, Tirry L, Vontas J, Tsagkarakou A: Acetylcholinesterase point mutations in European strains of Tetranychus urticae (Acari: Tetranychidae) resistant to organophosphates. Pest Manag Sci. 2010 Feb;66(2):220-8. The insecticide concentration needed to inhibit 50% of the AChE1 activity was, in the OP strains, at least 2.7, 55, 58 and 31 times higher for the OP pirimiphos-methyl, chlorpyrifos oxon, paraoxon and omethoate respectively, and 87 times higher for the CARB carbaryl. |
2(0,0,0,2) | Details |
| 12185494 | Pavlic M, Haidekker A, Grubwieser P, Rabl W: Fatal intoxication with omethoate. . Int J Legal Med. 2002 Aug;116(4):238-41. Epub 2002 Apr 17. The amount of the active AChE in peripheral blood serum was reduced to less than 0.2% of the normal level. |
1(0,0,0,1) | Details |
| 9491337 | He F, Xu H, Qin F, Xu L, Huang J, He X: Intermediate myasthenia syndrome following acute organophosphates poisoning--an analysis of 21 cases. Hum Exp Toxicol. 1998 Jan;17(1):40-5. The responsible OP insecticides included parathion, omethoate and some OP containing pesticide mixtures. Blood acetylcholinesterase activity was persistently inhibited. |
1(0,0,0,1) | Details |
| 12144698 | Vontas JG, Hejazi MJ, Hawkes NJ, Cosmidis N, Loukas M, Janes RW, Hemingway J: Resistance-associated point mutations of organophosphate insensitive acetylcholinesterase, in the olive fruit fly Bactrocera oleae. Insect Mol Biol. 2002 Aug;11(4):329-36. A comparison of cDNA sequences of individual insects from susceptible and resistant strains, coupled with an enzyme inhibition assay with omethoate, indicated a novel -serine substitution (G488S), at an amino acid residue which is highly conserved across species (G396 of Torpedocalifornica AChE), as a likely cause of AChE insensitivity. |
35(0,1,1,5) | Details |
| 8783813 | Worek F, Kirchner T, Backer M, Szinicz L: Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compounds. Arch Toxicol. 1996;70(8):497-503. For this purpose human erythrocyte AChE (EC 3.1.1.7) was inhibited (30 min) by chlorfenvinphos, dichlorvos, dicrotophos, heptenophos, mevinphos, monocrotophos, paraoxon, phosphamidon, trichlorfon, malaoxon, omethoate, oxydemeton-methyl or methamidophos by 85-98% of control. |
34(0,1,1,4) | Details |
| 15793557 | Isoda H, Talorete TP, Han J, Oka S, Abe Y, Inamori Y: Effects of organophosphorous pesticides used in china on various mammalian cells. Environ Sci. 2005;12(1):9-19. Five organophosphorous pesticides, monocrotophos, omethoate, parathion-methyl, phoxim and dichlorvos, were examined for their effects on mammalian cell lines to determine their potential impact on physiological functions in vivo. The different pesticides reduced the acetylcholinesterase (AChE) activity of the rat neuronal cell line PC12 in a dose-dependent manner up to 100 microM. |
1(0,0,0,1) | Details |
| 16042503 | Lotti M, Moretto A: Organophosphate-induced delayed polyneuropathy. . Toxicol Rev. 2005;24(1):37-49. The ratio of inhibitory powers for acetylcholinesterase and NTE represents the crucial guideline for the aetiological attribution of OP-induced peripheral neuropathy. We also discuss case reports where neuropathies were not convincingly attributed to fenthion, malathion, omethoate/dimethoate, parathion and merphos. |
1(0,0,0,1) | Details |
| 12915723 | Villatte F, Schulze H, Schmid RD, Bachmann TT: A long insertion reverts the functional effect of a substitution in acetylcholinesterase. Protein Eng. 2003 Jul;16(7):463-5. We introduced incrementally the single substitution W290A and a 26 amino acid long insertion at the 297 location in the Nippostrongylus brasiliensis acetylcholinesterase B sequence and analysed in vitro the induced changes in the hydrolysis rate of three hemi-substrates: pirimicarb, paraoxon methyl and omethoate. |
32(0,1,1,2) | Details |