Protein Information

Name epidermal growth factor receptors
Synonyms EGF receptor; EGFR; EGFR protein; ERBB; ERBB 1; ERBB1; Epidermal growth factor receptor; Epidermal growth factor receptor isoform a variant…

Compound Information

Name OCH
CAS 2,3,4,4,5,5,6,6-octachloro-2-cyclohexen-1-one

Reference List

PubMed Abstract RScore(About this table)
18804531 Eisinger DA, Ammer H: Delta-opioid receptors activate ERK/MAP kinase via integrin-stimulated receptor tyrosine kinases. Cell Signal. 2008 Dec;20(12):2324-31. Epub 2008 Sep 5.


Integrin-mediated cell adherence to extracellular matrix proteins results in stimulation of ERK1/2 activity, a mechanism involving focal adhesion tyrosine kinases (pp125FAK, Pyk-2) and epidermal growth factor receptors (EGFRs).
6(0,0,0,6) Details
12402303 Ruiter GA, Verheij M, Zerp SF, Moolenaar WH, Van Blitterswijk WJ: Submicromolar doses of alkyl-lysophospholipids induce rapid internalization, but not activation, of epidermal growth factor receptor and concomitant MAPK/ERK activation in A431 cells. Int J Cancer. 2002 Dec 1;102(4):343-50.


Strikingly, ALPs (500 nM) also trigger rapid clustering and internalization of the EGFR in A431 cells.
2(0,0,0,2) Details
11317493 Och W, Mariak Z, Smolka M, Badowski J, Koziorowski M: [Epidermal growth factor expression in brain neoplasms] . Neurol Neurochir Pol. 2000 Nov-Dec;34(6):1165-72.


Epidermal growth factor (EGF) influences the cell by activation of its specific cell receptor (EGFR).
1(0,0,0,1) Details
10834929 Bae SS, Perry DK, Oh YS, Choi JH, Galadari SH, Ghayur T, Ryu SH, Hannun YA, Suh PG: Proteolytic cleavage of phospholipase C-gamma1 during apoptosis in Molt-4 cells. FASEB J. 2000 Jun;14(9):1083-92.


Epidermal growth factor receptor (EGFR) -induced tyrosine phosphorylation of PLC-gamma1 resulted in resistance to cleavage by caspase-3 in vitro.
1(0,0,0,1) Details