Protein Information

Name caspase 9
Synonyms APAF 3; APAF3; Apoptotic protease MCH6; Apoptotic protease Mch 6; Apoptotic protease activating factor 3; CASP 9; CASP9; CASPASE 9c…

Compound Information

Name OCH
CAS 2,3,4,4,5,5,6,6-octachloro-2-cyclohexen-1-one

Reference List

PubMed Abstract RScore(About this table)
11919192 Sitailo LA, Tibudan SS, Denning MF: Activation of caspase-9 is required for UV-induced apoptosis of human keratinocytes. J Biol Chem. 2002 May 31;277(22):19346-52. Epub 2002 Mar 27.

4(0,0,0,4) Details
12660222 Maccarrone M, Battista N, Meloni M, Bari M, Galleri G, Pippia P, Cogoli A, Finazzi-Agro A: Creating conditions similar to those that occur during exposure of cells to microgravity induces apoptosis in human lymphocytes by 5-lipoxygenase-mediated mitochondrial uncoupling and cytochrome c release. J Leukoc Biol. 2003 Apr;73(4):472-81.


The caspase-3 and caspase-9 inhibitors Z-Asp (OCH (3))-Glu (OCH (3))-Val-Asp (OCH (3))-fluoromethylketone (FMK) and Z-Leu-Glu (OCH (3))-His-Asp (OCH (3))-FMK reduced apoptotic bodies to 25-30% of the control cells.
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10552970 Cuvillier O, Mayhew E, Janoff AS, Spiegel S: Liposomal ET-18-OCH (3) induces cytochrome c-mediated apoptosis independently of CD95 (APO-1/Fas) signaling. Blood. 1999 Nov 15;94(10):3583-92.


In addition, ELL-12 triggered release of cytochrome c from mitochondria to the cytoplasm before caspase-9 activation.
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