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Bojarski AJ, Paluchowska MH, Duszynska B, Klodzinska A, Tatarczynska E, Chojnacka-Wojcik E: 1-Aryl-4-(4-succinimidobutyl) piperazines and their conformationally constrained analogues: synthesis, binding to serotonin (5-HT1A, 5-HT2A, 5-HT7), alpha1-adrenergic, and dopaminergic D2 receptors, and in vivo 5-HT1A functional characteristics. Bioorg Med Chem. 2005 Mar 15;13(6):2293-303.
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Bojarski AJ, Paluchowska MH, Duszynska B, Bugno R, Klodzinska A, Tatarczynska E, Chojnacka-Wojcik E: Structure-intrinsic activity relationship studies in the group of 1-imido/amido substituted 4-(4-arylpiperazin-1-yl) cyclohexane derivatives; new, potent 5-HT1A receptor agents with anxiolytic- like activity. Bioorg Med Chem. 2006 Mar 1;14(5):1391-402. Epub 2005 Nov 2.
Some derivatives tested additionally showed also high affinity for alpha (1)-adrenergic receptors (K (i) = 2.9-101 nM) and for 5-HT (7) receptors. |
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