Protein Information

Name G proteins
Synonyms G gamma I; Guanine nucleotide binding protein 2; G protein; GNG 2; GNG2; GNGT 2; GNGT2; Guanine nucleotide binding protein gamma 2…

Compound Information

Name OCH
CAS 2,3,4,4,5,5,6,6-octachloro-2-cyclohexen-1-one

Reference List

PubMed Abstract RScore(About this table)
15194239 Piacentini MP, Piatti E, Fraternale D, Ricci D, Albertini MC, Accorsi A: Phospholipase C-dependent phosphoinositide breakdown induced by ELF-EMF in Peganum harmala calli. Biochimie. 2004 Apr-May;86(4-5):343-9.

The manipulation of the lipid-based signalling pathway by phosphoinositide-phospholipase C (PI-PLC) inhibitors (i.e., neomycin, U-73122 and ET-18-OCH (3)) seems to support the hypothesis that, as in animals, also in plants, the cell membrane is the primary impact site of ELF electromagnetic stimulus and that this interaction could probably involve the activation of PI signal transduction pathway including a heterotrimeric G protein.
31(0,1,1,1) Details
16365309 Lauckner JE, Hille B, Mackie K: The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19144-9. Epub 2005 Dec 19.

3(0,0,0,3) Details
10860858 Kane JK, Tanaka H, Parker SL, Yanagisawa M, Li MD: Sensitivity of orexin-A binding to phospholipase C inhibitors, neuropeptide Y, and secretin. Biochem Biophys Res Commun. 2000 Jun 16;272(3):959-65.


Up to 50% of the binding was sensitive to the G-protein nucleotide site agonist GTP-gamma-S.
1(0,0,0,1) Details
10938438 Narita M, Ohsawa M, Mizoguchi H, Aoki T, Suzuki T, Tseng LF: Role of the phosphatidylinositol-specific phospholipase C pathway in delta-opioid receptor-mediated antinociception in the mouse spinal cord. Neuroscience. 2000;99(2):327-31.


Stimulation of delta-opioid receptors has been shown to activate phospholipase C via the activation of G-proteins in vitro.
1(0,0,0,1) Details