Protein Information

Name MCAD
Synonyms CDH 3; MCAD; CDH3; Cadherin 3; CDH14; CDH15; CDHM; Cadherin 14…

Compound Information

Name OCH
CAS 2,3,4,4,5,5,6,6-octachloro-2-cyclohexen-1-one

Reference List

PubMed Abstract RScore(About this table)
19470521 Nishina Y, Sato K, Tamaoki H, Setoyama C, Miura R, Shiga K: FT-IR spectroscopic studies on the molecular mechanism for substrate specificity/activation of medium-chain acyl-CoA dehydrogenase. J Biochem. 2009 Sep;146(3):351-7. Epub 2009 May 26.


Thus, 8-NH (2)-FAD-MCAD is one of the attractive materials for investigation of enzyme-substrate (ES) interaction in ES complex (the complex of oxidized MCAD with acyl-CoA).
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17875556 Nishina Y, Sato K, Setoyama C, Tamaoki H, Miura R, Shiga K: Intramolecular and intermolecular perturbation on electronic state of FAD free in solution and bound to flavoproteins: FTIR spectroscopic study by using the C = O stretching vibrations as probes. J Biochem. 2007 Aug;142(2):265-72.


The 1,645-cm (-1) band containing C (2)=O stretching vibration shifted to 1,630 cm (-1) in the medium-chain acyl-CoA dehydrogenase (MCAD)-bound state, which can be explained by hydrogen bonds at C (2)=O of the flavin ring.
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