| Name | interleukin (protein family or complex) |
|---|---|
| Synonyms | Interleukin; Interleukins; interleukin receptor; interleukin receptors |
| Name | OCH |
|---|---|
| CAS | 2,3,4,4,5,5,6,6-octachloro-2-cyclohexen-1-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18067888 | McNally AK, Macewan SR, Anderson JM: Foreign body-type multinucleated giant cell formation requires protein kinase C beta, delta, and zeta. Exp Mol Pathol. 2008 Feb;84(1):37-45. Epub 2007 Nov 9. Here, we investigate the participation of protein kinase C (PKC) in the interleukin (IL)-4-induced fusion of human monocyte-derived macrophages and foreign body giant cell (FBGC) formation in vitro. |
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| 12392968 | Van Och FM, Van Loveren H, De Jong WH, Vandebriel RJ: Cytokine production induced by low-molecular-weight chemicals as a function of the stimulation index in a modified local lymph node assay: an approach to discriminate contact sensitizers from respiratory sensitizers. Toxicol Appl Pharmacol. 2002 Oct 1;184(1):46-56. In general, contact sensitizers have been shown to selectively induce Th1 immune responses, such as interferon-gamma (IFN-gamma) production, whereas Th2 responses, such as interleukin (IL)-4 production, were seen after exposure to respiratory allergens. |
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| 18698251 | Haeryfar SM, Lan Z, Leon-Ponte M, Duffy KR, Ge W, Liu W, Mele T, Garcia B, Wang H: Prolongation of cardiac allograft survival by rapamycin and the invariant natural killer T cell glycolipid agonist OCH. Transplantation. 2008 Aug 15;86(3):460-8. These were accompanied by elevated intragraft mRNA levels of interleukin (IL)-4, and to a lesser extent IL-10 and IL-13, and high transcript levels of Valpha14-Jalpha18 T-cell receptor gene segment. |
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| 16178791 | Miyake S, Yamamura T: Therapeutic potential of glycolipid ligands for natural killer (NK) T cells in the suppression of autoimmune diseases. Curr Drug Targets Immune Endocr Metabol Disord. 2005 Sep;5(3):315-22. OCH is a unique ligand to stimulate NKT cells to selectively produce Th2 cytokines whereas alpha-GC induces both interleukin (IL)-4 and interferon (IFN)-gamma, and is more beneficial for treatment of a wide variety of Th1-mediated autoimmune diseases. |
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