Protein Information

Name ATPase
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name OCH
CAS 2,3,4,4,5,5,6,6-octachloro-2-cyclohexen-1-one

Reference List

PubMed Abstract RScore(About this table)
20045694 Almeida-Amaral EE, Cardoso VC, Francioli FG, Meyer-Fernandes JR: Leishmania amazonensis: heme stimulates (Na (+)+K (+)) ATPase activity via phosphatidylinositol-specific phospholipase C/protein kinase C-like (PI-PLC/PKC) signaling pathways. Exp Parasitol. 2010 Apr;124(4):436-41. Epub 2010 Jan 4.

5(0,0,0,5) Details
12384249 Easton AS, Abbott NJ: Bradykinin increases permeability by calcium and 5-lipoxygenase in the ECV304/C6 cell culture model of the blood-brain barrier. Brain Res. 2002 Oct 25;953(1-2):157-69.


The store Ca (2+) ATPase inhibitor thapsigargin (1 microM) abolished the peak response.
1(0,0,0,1) Details
12890888 Kitamura Y, Miyamura A, Takata K, Inden M, Tsuchiya D, Nakamura K, Taniguchi T: Possible involvement of both endoplasmic reticulum-and mitochondria-dependent pathways in thapsigargin-induced apoptosis in human neuroblastoma SH-SY5Y cells. J Pharmacol Sci. 2003 Jul;92(3):228-36.


Thapsigargin, an inhibitor of ER-associated Ca (2+)-ATPase, induced the degradation of caspase-12-like protein.
1(0,0,0,1) Details
15929741 Sawisky GR, Chang JP: Intracellular calcium involvement in pituitary adenylate cyclase-activating polypeptide stimulation of growth hormone and gonadotrophin secretion in goldfish pituitary cells. J Neuroendocrinol. 2005 Jun;17(6):353-71.


Two endoplasmic/sarcoplasmic reticulum Ca (2+) ATPase (SERCA) inhibitors, thapsigargin and cyclopiazonic acid, augmented PACAP-induced GTH-II release; similarly, thapsigargin elevated GH responses to PACAP.
1(0,0,0,1) Details