| Name | CD40 |
|---|---|
| Synonyms | B cell associated molecule CD40; p50; B cell surface antigen CD40; Bp50; CD40; CD40 antigen isoform 1; CD40 antigen isoform 1 precursor; CD40L receptor… |
| Name | OCH |
|---|---|
| CAS | 2,3,4,4,5,5,6,6-octachloro-2-cyclohexen-1-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15599405 | Silk JD, Hermans IF, Gileadi U, Chong TW, Shepherd D, Salio M, Mathew B, Schmidt RR, Lunt SJ, Williams KJ, Stratford IJ, Harris AL, Cerundolo V: Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy. J Clin Invest. 2004 Dec;114(12):1800-11. Activation of invariant CD1d-dependent NK T cells (iNKT cells) in vivo through administration of the glycolipid ligand alpha-galactosylceramide (alpha-GalCer) or the -truncated alpha-GalCer analog OCH leads to CD40 signaling as well as the release of soluble molecules including type 1 and gamma interferons that contribute to DC maturation. |
1(0,0,0,1) | Details |
| 16291659 | Oki S, Tomi C, Yamamura T, Miyake S: Preferential T (h) 2 polarization by OCH is supported by incompetent NKT cell induction of CD40L and following production of inflammatory cytokines by bystander cells in vivo. Int Immunol. 2005 Dec;17(12):1619-29. Epub 2005 Nov 15. Co-injection of a sub-optimal dose of IFN-gamma and stimulatory anti-CD40 mAb compensates for the lower induction of IL-12 by OCH administration. |
1(0,0,0,1) | Details |
| 14607913 | Hermans IF, Silk JD, Gileadi U, Salio M, Mathew B, Ritter G, Schmidt R, Harris AL, Old L, Cerundolo V: NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells. J Immunol. 2003 Nov 15;171(10):5140-7. This enhancement was dependent on the involvement of iNKT cells and CD1d molecules and required CD40 signaling. |
1(0,0,0,1) | Details |