Protein Information

Name cytochrome P450 (protein family or complex)
Synonyms cytochrome P450; cytochrome P 450; CYP450; CYP 450

Compound Information

Name OCH
CAS 2,3,4,4,5,5,6,6-octachloro-2-cyclohexen-1-one

Reference List

PubMed Abstract RScore(About this table)
10727902 Kappers WA, van Och FM, de Groene EM, Horbach GJ: Comparison of three different in vitro mutation assays used for the investigation of cytochrome P450-mediated mutagenicity of nitro-polycyclic aromatic hydrocarbons. Mutat Res. 2000 Mar 23;466(2):143-59.

3(0,0,0,3) Details
11457014 de Visser SP, Ogliaro F, Harris N, Shaik S: Multi-state epoxidation of ethene by cytochrome P450: a quantum chemical study. J Am Chem Soc. 2001 Apr 4;123(13):3037-47.

2(0,0,0,2) Details
12022842 Rivera M, Caignan GA, Astashkin AV, Raitsimring AM, Shokhireva TKh, Walker FA: Models of the low-spin iron (III) hydroperoxide intermediate of heme oxygenase: magnetic resonance evidence for thermodynamic stabilization of the d (xy) electronic state at ambient temperatures. J Am Chem Soc. 2002 May 29;124(21):6077-89.


Because of the similarity in the EPR spectra of the hydroperoxide complexes of heme oxygenase, cytochrome P450, and the model heme complex reported herein, it is possible that these two electron configurations and ring conformations may also exist in equilibrium in the enzymatic systems.
1(0,0,0,1) Details
12143142 Rojdmark S, von Bahr C: [Metabolic interaction between psychopharmaceuticals. Lakartidningen. 2002 Jun 20;99(25):2854-6.


Most psychotropic drugs are metabolized in the liver by cytochrome P450.
1(0,0,0,1) Details
17582757 Lu F, Zahid M, Saeed M, Cavalieri EL, Rogan EG: Estrogen metabolism and formation of estrogen-DNA adducts in estradiol-treated MCF-10F cells. J Steroid Biochem Mol Biol. 2007 Jun-Jul;105(1-5):150-8. Epub 2007 May 16.


MCF-10F cells were treated with TCDD, a cytochrome P450 inducer, then with E (2) and Ro41-0960, a COMT inhibitor.
1(0,0,0,1) Details