| Name | IL 4 |
|---|---|
| Synonyms | B cell differentiation factor gamma; B cell growth factor; B cell stimulatory factor 1; BCDF gamma; BCDFg; BCDFgamma; BCGF; BSF 1… |
| Name | OCH |
|---|---|
| CAS | 2,3,4,4,5,5,6,6-octachloro-2-cyclohexen-1-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16291659 | Oki S, Tomi C, Yamamura T, Miyake S: Preferential T (h) 2 polarization by OCH is supported by incompetent NKT cell induction of CD40L and following production of inflammatory cytokines by bystander cells in vivo. Int Immunol. 2005 Dec;17(12):1619-29. Epub 2005 Nov 15. Although we have previously shown the intrinsic molecular mechanism of preferential IL-4 production by OCH-stimulated NKT cells, little is known about the extrinsic regulatory network for IFN-gamma production. |
3(0,0,0,3) | Details |
| 15173890 | Oki S, Chiba A, Yamamura T, Miyake S: The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells. J Clin Invest. 2004 Jun;113(11):1631-40. |
3(0,0,0,3) | Details |
| 12392968 | Van Och FM, Van Loveren H, De Jong WH, Vandebriel RJ: Cytokine production induced by low-molecular-weight chemicals as a function of the stimulation index in a modified local lymph node assay: an approach to discriminate contact sensitizers from respiratory sensitizers. Toxicol Appl Pharmacol. 2002 Oct 1;184(1):46-56. In general, contact sensitizers have been shown to selectively induce Th1 immune responses, such as interferon-gamma (IFN-gamma) production, whereas Th2 responses, such as interleukin (IL)-4 production, were seen after exposure to respiratory allergens. |
3(0,0,0,3) | Details |
| 15336266 | Matsuda H, Tewtrakul S, Morikawa T, Yoshikawa M: Anti-allergic activity of stilbenes from Korean rhubarb (Rheum undulatum L.): structure requirements for inhibition of antigen-induced degranulation and their effects on the release of TNF-alpha and IL-4 in RBL-2H3 cells. Bioorg Med Chem. 2004 Sep 15;12(18):4871-6. |
2(0,0,0,2) | Details |
| 15674111 | Ueno Y, Tanaka S, Sumii M, Miyake S, Tazuma S, Taniguchi M, Yamamura T, Chayama K: Single dose of OCH improves mucosal T helper type 1/T helper type 2 cytokine balance and prevents experimental colitis in the presence of valpha14 natural killer T cells in mice. Inflamm Bowel Dis. 2005 Jan;11(1):35-41. Interferon-gamma and interleukin-4 levels in the supernatants from colonic lamina propria lymphocytes (LPLs) were measured by enzyme-linked immunosorbent assay. |
2(0,0,0,2) | Details |
| 16447760 | Yamamura T: [Synthetic glycolipid ligands as novel therapeutics for multiple sclerosis]. Rinsho Shinkeigaku. 2005 Nov;45(11):909-11. The unique glycolipid-reactive lymphocytes are known to produce a large quantity of Th2 cytokines such as IL-4 when encountering their ligands like alpha-galactosylceramide (alpha-GC). |
2(0,0,0,2) | Details |
| 18067888 | McNally AK, Macewan SR, Anderson JM: Foreign body-type multinucleated giant cell formation requires protein kinase C beta, delta, and zeta. Exp Mol Pathol. 2008 Feb;84(1):37-45. Epub 2007 Nov 9. Here, we investigate the participation of protein kinase C (PKC) in the interleukin (IL)-4-induced fusion of human monocyte-derived macrophages and foreign body giant cell (FBGC) formation in vitro. |
1(0,0,0,1) | Details |
| 14965307 | Yamamura T, Miyamoto K, Illes Z, Pal E, Araki M, Miyake S: NKT cell-stimulating synthetic glycolipids as potential therapeutics for autoimmune disease. Curr Top Med Chem. 2004;4(5):561-7. However, we found that an altered analogue of alpha-GalCer with a shorter chain (OCH), is more useful than alpha-GalCer for treatment of autoimmune disease models, because of its ability to selectively induce IL-4, a key cytokine for control of autoimmunity. |
1(0,0,0,1) | Details |
| 16178791 | Miyake S, Yamamura T: Therapeutic potential of glycolipid ligands for natural killer (NK) T cells in the suppression of autoimmune diseases. Curr Drug Targets Immune Endocr Metabol Disord. 2005 Sep;5(3):315-22. OCH is a unique ligand to stimulate NKT cells to selectively produce Th2 cytokines whereas alpha-GC induces both interleukin (IL)-4 and interferon (IFN)-gamma, and is more beneficial for treatment of a wide variety of Th1-mediated autoimmune diseases. |
1(0,0,0,1) | Details |
| 16323834 | Ndonye RM, Izmirian DP, Dunn MF, Yu KO, Porcelli SA, Khurana A, Kronenberg M, Richardson SK, Howell AR: Synthesis and evaluation of analogues of KRN7000 and OCH. J Org Chem. 2005 Dec 9;70(25):10260-70. We have prepared the direct -containing analogues of KRN7000 and OCH, 1 and 2, and found them to be comparable in activity to the parent compounds in inducing the release of IL-2, IL-4, and IFNgamma. |
1(0,0,0,1) | Details |
| 19481452 | Velmourougane G, Raju R, Bricard G, Im JS, Besra GS, Porcelli SA, Howell AR: Synthesis and evaluation of an acyl-chain unsaturated analog of the Th2 biasing, immunostimulatory glycolipid, OCH. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3386-8. Epub 2009 May 18. An alpha-galactosyl (alpha-GalCer) 2 was synthesized and evaluated for its ability to stimulate iNKT-cell proliferation and elicit T-helper cytokines, IL-4 and IFNgamma. |
1(0,0,0,1) | Details |
| 14730629 | Chiba A, Oki S, Miyamoto K, Hashimoto H, Yamamura T, Miyake S: Suppression of collagen-induced arthritis by natural killer T cell activation with OCH, a -truncated analog of alpha-galactosylceramide. Arthritis Rheum. 2004 Jan;50(1):305-13. Neutralization of interleukin-4 (IL-4) or IL-10 with monoclonal antibodies abolished disease protection by OCH, indicating a critical role for these cytokines. |
1(0,0,0,1) | Details |
| 18698251 | Haeryfar SM, Lan Z, Leon-Ponte M, Duffy KR, Ge W, Liu W, Mele T, Garcia B, Wang H: Prolongation of cardiac allograft survival by rapamycin and the invariant natural killer T cell glycolipid agonist OCH. Transplantation. 2008 Aug 15;86(3):460-8. These were accompanied by elevated intragraft mRNA levels of interleukin (IL)-4, and to a lesser extent IL-10 and IL-13, and high transcript levels of Valpha14-Jalpha18 T-cell receptor gene segment. |
1(0,0,0,1) | Details |
| 18802082 | Grajewski RS, Hansen AM, Agarwal RK, Kronenberg M, Sidobre S, Su SB, Silver PB, Tsuji M, Franck RW, Lawton AP, Chan CC, Caspi RR: Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responses. J Immunol. 2008 Oct 1;181(7):4791-7. Surprisingly, superior protection against EAU was achieved with alpha-C-GalCer, which induces a strong IFN-gamma but only a weak IL-4 production by iNKT cells, in contrast to the ligands alpha-GalCer (both IFN-gamma and IL-4) and OCH (primarily IL-4). |
1(0,0,0,1) | Details |