| 10882017 |
Yoon SH, Wu J, Wu WM, Prokai L, Bodor N: Brain-targeted chemical delivery of [Leu2, Pip3]-TRH: synthesis and biological evaluation. Bioorg Med Chem. 2000 May;8(5):1059-63.
Sequential metabolism of the obtained 'packaged' chemical delivery system, (CDS), DHT-Pro-Pro-Gln-Leu-Pip-OCh, should yield a 'locked-in' precursor following the oxidative conversion of the dihydrotrigonellyl (DHT) to the trigonellyl (T+) moiety, followed by removal of the cholesteryl function and cleavage of the T+-Pro-Pro by prolyl endopeptidase. |
81(1,1,1,1) |
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