Protein Information

Name catalase
Synonyms CAT; Catalase; Erythrocyte derived growth promoting factor; Carnitine O acetyltransferase; Carnitine acetylase; Carnitine acetyltransferase; CAT; Catalases…

Compound Information

Name 2-phenylphenol
CAS [1,1′-biphenyl]-2-ol

Reference List

PubMed Abstract RScore(About this table)
7517511 Tayama S, Nakagawa Y: Effect of scavengers of active oxygen species on cell damage caused in CHO-K1 cells by phenylhydroquinone, an o-phenylphenol metabolite. Mutat Res. 1994 Jul;324(3):121-31.


These effects were inhibited by catalase (280 U/ml), a scavenger of hydrogen peroxide (H2O2), as well as by the reductants, ascorbate (3 mM) and GSH (1 mM).
3(0,0,0,3) Details
7728964 Nagai F, Ushiyama K, Satoh K, Kasai H, Kano I: Formation of 8-hydroxydeoxyguanosine in calf thymus DNA treated in vitro with phenylhydroquinone, the major metabolite of O-phenylphenol. Carcinogenesis. 1995 Apr;16(4):837-40.


The formation of 8OHdG by PHQ was reduced by oxygen radical scavengers such as catalase, sodium benzoate and sodium azide.
1(0,0,0,1) Details
17251053 Tani S, Yonezawa Y, Morisawa S, Nishioka H: Development of a new E. coli strain to detect oxidative mutation and its application to the fungicide o-phenylphenol and its metabolites. Mutat Res. 2007 Apr 2;628(2):123-8. Epub 2006 Dec 27.


However, in Escherichia coli (E. coli), ROS are eliminated by enzymes such as superoxide dismutase and catalase, which are coded by sodAB and katEG genes.
1(0,0,0,1) Details
2130942 Inoue S, Yamamoto K, Kawanishi S: DNA damage induced by metabolites of o-phenylphenol in the presence of copper (II) ion. Chem Res Toxicol. 1990 Mar-Apr;3(2):144-9.


Catalase, methionine, and methional inhibited the DNA damage completely, whereas mannitol, sodium formate, ethanol, tert-butyl alcohol, and superoxide dismutase did not. 2,5-Dihydroxybiphenyl plus Cu (II) frequently induced a piperidine-labile site at thymine and guanine residues.
1(0,0,0,1) Details
2171789 Nagai F, Ushiyama K, Satoh K, Kano I: DNA cleavage by phenylhydroquinone: the major metabolite of a fungicide o-phenylphenol. Chem Biol Interact. 1990;76(2):163-79.


The DNA cleavage by PHQ was inhibited by superoxide dismutase (SOD), catalase and several oxygen radical scavengers such as polyethylene glycol, tert-butanol, dimethyl sulfoxide, sodium azide, sodium benzoate, bovine serum albumin and methionine.
1(0,0,0,1) Details
10334203 Murata M, Moriya K, Inoue S, Kawanishi S: Oxidative damage to cellular and isolated DNA by metabolites of a fungicide ortho-phenylphenol. Carcinogenesis. 1999 May;20(5):851-7.


Catalase and bathocuproine inhibited Cu (II)-mediated DNA damage by PBQ plus NADH and PHQ, suggesting that H2O2 reacts with Cu (I) to produce active species causing DNA damage.
1(0,0,0,1) Details