| Name | Lipoxygenase (protein family or complex) |
|---|---|
| Synonyms | arachidonate lipoxygenase; arachidonate lipoxygenases; lipoxygenase; lipoxygenases |
| Name | ethoxyquin |
|---|---|
| CAS | 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3928952 | Miyazawa K, Iimori Y, Makino M, Mikami T, Miyasaka K: Effects of some non-steroidal anti-inflammatory drugs and other agents on cyclooxygenase and lipoxygenase activities in some enzyme preparations. Jpn J Pharmacol. 1985 Jun;38(2):199-205. BW755C, 1-phenyl-3-pyrazolidone (phenidone), toluene-3,4-dithiol (dithiol), 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline (ethoxyquin) and phenylhydrazone (APH) inhibited both enzyme activities. |
2(0,0,0,2) | Details |
| 2571427 | Denda A, Ura H, Tsujiuchi T, Tsutsumi M, Eimoto H, Takashima Y, Kitazawa S, Kinugasa T, Konishi Y: Possible involvement of arachidonic acid metabolism in phenobarbital promotion of hepatocarcinogenesis. Carcinogenesis. 1989 Oct;10(10):1929-35. Among the antioxidants investigated, did not affect, but n-propyl and ethoxyquin exerted a dose-dependent inhibition of PB promotion. These results are strongly suggestive of an involvement of phospholipase A2, lipoxygenase and cyclooxygenase metabolic pathways in the mechanisms underlying PB enhancement of hepatocarcinogenesis. |
1(0,0,0,1) | Details |
| 2539462 | Spaethe SM, Hsueh W, Needleman P: Pharmacological manipulation of inflammation in rabbit hydronephrosis: effects of a combined cyclooxygenase/lipoxygenase inhibitor ethoxyquin, a thromboxane synthase inhibitor RS-5186 and a PAF antagonist L-659,989. J Pharmacol Exp Ther. 1989 Mar;248(3):1308-16. |
62(0,2,2,2) | Details |
| 6765914 | Zenser TV, Mattammal MB, Davis BB: Metabolism of N-[4-(5-nitro-2-furyl)-2-thiazolyl] by prostaglandin endoperoxide synthetase. Cancer Res. 1980 Jan;40(1):114-8. Structurally dissimilar inhibitors of prostaglandin endoperoxide synthetase such as indomethacin, 5,8,11,14-eicosatetraynoic acid, ethoxyquin, and meclofenamic acid specifically inhibited FANFT metabolism. |
0(0,0,0,0) | Details |
| 7400670 | Zenser TV, Mattammal MB, Davis BB: Co-oxidative metabolism of 2-amino-4-(5-nitro-2-furyl)-thiazole by prostaglandin hydroperoxidase. J Lab Clin Med. 1980 Sep;96(3):425-32. Cumene hydroperoxide-mediated co-oxidation was not prevented by indomethacin or SKF-525A but was blocked by the antioxidants butylated hydroxytoluene, ethoxyquin, and |
0(0,0,0,0) | Details |