| Name | transferase |
|---|---|
| Synonyms | 4' phosphopantetheinyl transferase; 4' phosphopantetheinyl transferase; AASD PPT; AASDHPPT; AASDPPT; Alpha aminoadipic semialdehyde dehydrogenase phosphopantetheinyl transferase; Aminoadipate semialdehyde dehydrogenase phosphopantetheinyl transferase; CGI 80… |
| Name | ethoxyquin |
|---|---|
| CAS | 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11309284 | McMahon M, Itoh K, Yamamoto M, Chanas SA, Henderson CJ, McLellan LI, Wolf CR, Cavin C, Hayes JD: The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and biosynthetic enzymes. Cancer Res. 2001 Apr 15;61(8):3299-307. Both Nrf2-/- and Nrf2+/+ mice were fed a control diet or one supplemented with either synthetic cancer chemopreventive agents [butylated hydroxyanisole (BHA), ethoxyquin (EQ), or oltipraz] or phytochemicals cafestol and kahweol (CMRN), or alpha-angelicalactone]. Immunoblotting class-alpha and class-mu GST showed that constitutive expression of most transferase subunits is also reduced in the small intestine of Nrf2 mutant mice. |
1(0,0,0,1) | Details |
| 19695238 | Lubet RA, Yao R, Grubbs CJ, You M, Wang Y: Induced expression of drug metabolizing enzymes by preventive agents: role of the antioxidant response element. Chem Biol Interact. 2009 Nov 10;182(1):22-8. Epub 2009 Aug 18. The agents examined, which might be expected to respond via specific nuclear receptors (CAR, AhR) as well as antioxidant response elements (AREs), included Phase I/II inducers [5,6-benzoflavone (BF, 5000mg/kg diet), diallyl sulfide (DAS, 500mg/kg BW/day), ethoxyquin (EXO, 300mg/kg BW/day) and phenobarbital (PB, 500mg/kg diet)] or pure Phase II inducers [1,2-dithiol-3-thione (DTT, 500mg/kg diet), and cyclopentadithiolthione (CPDTT, 175mg/kg BW/day)]. In genes with known AREs, the induction ratios (Levels Treated/Levels Controls) were: quinone oxidoreductase (BF, 8:1; DTT, 3.2:1; CPDTT, 3:1; DAS, 1.8:1; Exo, 1.7:1), transferase Pi (DTT, 36:1; CPDTT, 34:1; EXO, 8:1; DAS, 5:1; BF, 2.5:1), and keto reductase 7A3 (AFAR) (DTT and CPDTT, 14:1; DAS, 6:1; EXO, 4:1; PB, 1.5:1). |
1(0,0,0,1) | Details |
| 3630203 | Stewart J, Boston CM: Effect of pretreatment with 3-methylcholanthrene and several phenolic antioxidants on glutathione S-transferase activity in various tissues of female Sprague-Dawley rats. Xenobiotica. 1987 Jun;17(6):679-84. In the extra-hepatic tissues using 1-chloro-2,4-dinitrobenzene as a substrate, all treatments caused an increase in transferase activity in the lung; ethoxyquin and combined methylcholanthrene plus butylated hydroxyanisole increased this activity in the kidney, whereas only the combined methylcholanthrene plus butylated hydroxyanisole increased activity in the small intestine. 5. |
33(0,1,1,3) | Details |
| 7482539 | Buetler TM, Gallagher EP, Wang C, Stahl DL, Hayes JD, Eaton DL: Induction of phase I and phase II drug-metabolizing enzyme mRNA, protein, and activity by BHA, ethoxyquin, and oltipraz. Toxicol Appl Pharmacol. 1995 Nov;135(1):45-57. In this study, rats were treated with the monofunctional inducers tert-butylated hydroxyanisole, ethoxyquin, and oltipraz to study the inducibility of individual glutathione S-transferase isozymes, (H):quinone oxidoreductase, gamma-glutamylcysteine synthetase, UDP-glucuronosyl transferase, and cytochrome P450 enzymes. |
6(0,0,1,1) | Details |
| 2565179 | Makary M, Kim HL, Safe S, Womack J, Ivie GW: Induction of glutathione S-transferases in genetically inbred male mice by dietary ethoxyquin hydrochloride. Comp Biochem Physiol C. 1989;92(2):171-4. The constitutive GSH S-transferase (GST) activity varied from 2.9 (SJL/JCR) to 8.9 (C57BL/6NCR) mumol product formed/min/mg protein and the corresponding values for the EQ-HCl-treated mice were in the range of 15.3-25.3 mumol product formed/min/mg protein. 3. |
1(0,0,0,1) | Details |
| 16790489 | Berdikova Bohne VJ, Hamre K, Arukwe A: Hepatic biotransformation and metabolite profile during a 2-week depuration period in Atlantic salmon fed graded levels of the synthetic antioxidant, ethoxyquin. Toxicol Sci. 2006 Sep;93(1):11-21. Epub 2006 Jun 21. Consumption of dietary EQ produced the expression of CYP3A, glutathione S-transferase (GST), and glucuronosyl-transferase (UDPGT) mRNA during the depuration period. |
1(0,0,0,1) | Details |
| 6678746 | Cha YN, Heine HS, Ansher S: Comparative effects of dietary administration of antioxidants and inducers on the activities of several hepatic enzymes in mice. Drug Nutr Interact. 1983;2(1):35-45. Feeding mice with anticarcinogenic antioxidants, 2 (3)-tert-butyl-4-hydroxyanisole (BHA), ethoxyquin (EQ), disulfiram (DSF), and selenite (SE) resulted in selective changes in hepatic microsomal mixed function oxidases and in other enzymatic activities which were different from those obtained by feeding phenobarbital (PB), 3-methyl cholanthrene (MC), and Aroclor (ARO). |
0(0,0,0,0) | Details |