| Name | quinone reductase |
|---|---|
| Synonyms | Quinone oxidoreductase; Crystallin zeta; Zeta crystallin; Crystallin zetas; Quinone oxidoreductases; Zeta crystallins; CRYZ; Zeta crystalline… |
| Name | ethoxyquin |
|---|---|
| CAS | 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19695238 | Lubet RA, Yao R, Grubbs CJ, You M, Wang Y: Induced expression of drug metabolizing enzymes by preventive agents: role of the antioxidant response element. Chem Biol Interact. 2009 Nov 10;182(1):22-8. Epub 2009 Aug 18. The agents examined, which might be expected to respond via specific nuclear receptors (CAR, AhR) as well as antioxidant response elements (AREs), included Phase I/II inducers [5,6-benzoflavone (BF, 5000mg/kg diet), diallyl sulfide (DAS, 500mg/kg BW/day), ethoxyquin (EXO, 300mg/kg BW/day) and phenobarbital (PB, 500mg/kg diet)] or pure Phase II inducers [1,2-dithiol-3-thione (DTT, 500mg/kg diet), and cyclopentadithiolthione (CPDTT, 175mg/kg BW/day)]. In genes with known AREs, the induction ratios (Levels Treated/Levels Controls) were: quinone oxidoreductase (BF, 8:1; DTT, 3.2:1; CPDTT, 3:1; DAS, 1.8:1; Exo, 1.7:1), transferase Pi (DTT, 36:1; CPDTT, 34:1; EXO, 8:1; DAS, 5:1; BF, 2.5:1), and keto reductase 7A3 (AFAR) (DTT and CPDTT, 14:1; DAS, 6:1; EXO, 4:1; PB, 1.5:1). |
2(0,0,0,2) | Details |
| 8665510 | Ellis EM, Judah DJ, Neal GE, O'Connor T, Hayes JD: Regulation of carbonyl-reducing enzymes in rat liver by chemoprotectors. Cancer Res. 1996 Jun 15;56(12):2758-66. This method has been used to show that, in addition to AFAR, two other rat liver carbonyl-reducing enzymes are induced by ethoxyquin, and that these are distinct from NAD (P) H: quinone oxidoreductase. |
31(0,1,1,1) | Details |
| 6180607 | Talalay P, Benson AM: Elevation of quinone reductase activity by anticarcinogenic antioxidants. Adv Enzyme Regul. 1982;20:287-300. We have observed that quinone reductase specific activity is increased markedly in mouse liver and several extrahepatic tissues in response to dietary BHA, ethoxyquin, and disulfiram, whereas BHT has been shown by others to enhance this enzymatic activity in rat liver. |
12(0,0,1,7) | Details |
| 11448651 | Guyonnet D, Belloir C, Suschetet M, Siess MH, Le Bon AM: Antimutagenic activity of organosulfur compounds from Allium is associated with phase II enzyme induction. Mutat Res. 2001 Aug 22;495(1-2):135-45. Interestingly, DADS appeared to be as effective as ethoxyquin, a model inducer of phase II enzymes, in both inducing phase II enzymes and inhibiting the mutagenicity of carcinogens. DADS strongly increased all the phase II enzymes activities examined, i.e. total glutathione S-transferase (GST) activity, mu GST activity, quinone reductase (QR) activity and epoxide hydrolase (EH) activity. |
1(0,0,0,1) | Details |
| 9328168 | Manson MM, Ball HW, Barrett MC, Clark HL, Judah DJ, Williamson G, Neal GE: Mechanism of action of dietary chemoprotective agents in rat liver: induction of phase I and II drug metabolizing enzymes and metabolism. Carcinogenesis. 1997 Sep;18(9):1729-38. A range of potential chemoprotective agents, most of them natural dietary constituents, has been examined for ability to modulate both phase I (cytochrome P450 1A1, 1A2, 2B1/2, 2C11, 2E1, 3A, 4A) and phase II drug metabolizing enzymes (glutathione S-transferases, in particular subunits Yc2 and P, -aldehyde reductase and quinone reductase) in rat liver. Of the compounds examined, butylated hydroxytoluene, ethoxyquin, and phenethyl isothiocyanate were the most potent bifunctional agents (inducing both phase I and II activities). |
1(0,0,0,1) | Details |
| 10706111 | Kelly VP, Ellis EM, Manson MM, Chanas SA, Moffat GJ, McLeod R, Judah DJ, Neal GE, Hayes JD: Chemoprevention of hepatocarcinogenesis by a natural benzopyrone that is a potent inducer of -aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD (P) H:quinone oxidoreductase in rat liver. Cancer Res. 2000 Feb 15;60(4):957-69. Treatment with either phytochemicals [benzyl isothiocyanate, (CMRN), or or synthetic antioxidants and other drugs (butylated hydroxyanisole, diethyl ethoxyquin, beta-naphthoflavone, oltipraz, phenobarbital, or trans-stilbene oxide) has been found to increase hepatic aldo-keto reductase activity toward -dialdehyde and glutathione S-transferase (GST) activity toward -8,9-epoxide in both male and female rats. |
0(0,0,0,0) | Details |