Protein Information

Name microtubule associated proteins
Synonyms GOLSYN; Golgi localized syntaphilin related protein; Golgi localized syntaphilin related proten A; Golgi localized syntaphilin related proten B; Golgi localized syntaphilin related proten C; Microtubule associated protein; SYBU; Syntabulin…

Compound Information

Name oryzalin
CAS 4-(dipropylamino)-3,5-dinitrobenzenesulfonamide

Reference List

PubMed Abstract RScore(About this table)
17337629 Wang X, Zhu L, Liu B, Wang C, Jin L, Zhao Q, Yuan M: Arabidopsis MICROTUBULE-ASSOCIATED PROTEIN18 functions in directional cell growth by destabilizing cortical microtubules. Plant Cell. 2007 Mar;19(3):877-89. Epub 2007 Mar 2.


Microtubule-associated proteins (MAPs) play important roles in the regulation of microtubule function in cells.
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10744861 Moore RC, Cyr RJ: Association between elongation factor-1alpha and microtubules in vivo is domain dependent and conditional. Cell Motil Cytoskeleton. 2000 Apr;45(4):279-92.

Furthermore, domain III stabilizes cortical microtubules as determined by their resistance to the anti-microtubule herbicide, oryzalin.
Although the precise definition for a microtubule-associated protein (MAP) has been the subject of debate, elongation factor-1alpha (EF-1alpha) fits the most basic criteria for a MAP [Durso and Cyr, 1994a].
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17873093 Ambrose JC, Shoji T, Kotzer AM, Pighin JA, Wasteneys GO: The Arabidopsis CLASP gene encodes a microtubule-associated protein involved in cell expansion and division. Plant Cell. 2007 Sep;19(9):2763-75. Epub 2007 Sep 14.

Overexpression of CLASP promotes microtubule bundles that are resistant to depolymerization with oryzalin.
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11154346 Marcus AI, Moore RC, Cyr RJ: The role of microtubules in guard cell function. . Plant Physiol. 2001 Jan;125(1):387-95.

Furthermore, guard cells treated with the anti-microtubule drugs, propyzamide, oryzalin, and trifluralin also failed to open under the same environmental conditions.
In a mechanistic manner, evidence is presented to implicate a microtubule-associated protein in this putative microtubule-based signal transduction event.
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