Protein Information

Name calcium channel (protein family or complex)
Synonyms calcium channel

Compound Information

Name oryzalin
CAS 4-(dipropylamino)-3,5-dinitrobenzenesulfonamide

Reference List

PubMed Abstract RScore(About this table)
9681002 Thion L, Mazars C, Nacry P, Bouchez D, Moreau M, Ranjeva R, Thuleau P: Plasma membrane depolarization-activated calcium channels, stimulated by microtubule-depolymerizing drugs in wild-type Arabidopsis thaliana protoplasts, display constitutively large activities and a longer half-life in ton 2 mutant cells affected in the organization of cortical microtubules. Plant J. 1998 Mar;13(5):603-10.

In addition, oryzalin and colchicine, which disrupt the microtubule organization, stimulated and stabilized calcium channel activities in wild-type but remained ineffective on ton 2 protoplasts.
7(0,0,1,2) Details
8804414 Thion L, Mazars C, Thuleau P, Graziana A, Rossignol M, Moreau M, Ranjeva R: Activation of plasma membrane voltage-dependent calcium-permeable channels by disruption of microtubules in carrot cells. FEBS Lett. 1996 Sep 9;393(1):13-8.

Thus, the addition of colchicine or oryzalin, which are known to disrupt microtubule organization, leads to a 6-10-fold increase in calcium channel activities and half-life.
6(0,0,1,1) Details
17906320 Wang C, Li J, Yuan M: Salt tolerance requires cortical microtubule reorganization in Arabidopsis. Plant Cell Physiol. 2007 Nov;48(11):1534-47. Epub 2007 Sep 28.

Stabilization of microtubules with paclitaxel resulted in more seedling death under salt stress, while disruption of microtubules with oryzalin or propyzamide rescued seedlings from death.
This rescue effect was abolished by removing calcium from the medium or treatment with a calcium channel inhibitor.
1(0,0,0,1) Details