Protein Information

Name SK 2
Synonyms SK 2; SPHK 2; SPHK2; SPK 2; SPK2; Sphingosine kinase 2; Sphingosine kinase 2s

Compound Information

Name MAA
CAS methylarsonic acid

Reference List

PubMed Abstract RScore(About this table)
2076895 Shockley TR, Mandeville JT, Tompkins RG, Yarmush ML: Equilibrium binding characteristics of monoclonal antibodies recognizing melanoma cell surface antigens. Hybridoma. 1990 Dec;9(6):527-44.


The equilibrium binding characteristics of a panel of six monoclonal antibodies (MAb) recognizing melanoma cell surface antigens (125 kdal cell surface melanoma associated glycoprotein antigen, 125kD-MAA; high molecular weight melanoma associated antigen, HMW-MAA; and a non-protein melanoma associated antigen, NP-MAA) were investigated using the cell lines SK-MEL-2, SK-MEL-5, and M21.
1(0,0,0,1) Details
1728407 Shockley TR, Lin K, Sung C, Nagy JA, Tompkins RG, Dedrick RL, Dvorak HF, Yarmush ML: A quantitative analysis of tumor specific monoclonal antibody uptake by human melanoma xenografts: effects of antibody immunological properties and tumor antigen expression levels. Cancer Res. 1992 Jan 15;52(2):357-66.


The time-dependent (5 min-72 h) localization of 3 radiolabeled anti-melanoma monoclonal antibodies (MAbs 436, IND1, and 9.2.27) was studied in paired label experiments in small (4-12 mg) s.c. human melanoma xenografts (SK-MEL-2 and M21) in athymic nude mice.
3(0,0,0,3) Details
10203062 Chan MC, Murphy RM: Kinetics of cellular trafficking and cytotoxicity of 9.2.27-gelonin immunotoxins targeted against the high-molecular-weight melanoma-associated antigen. Cancer Immunol Immunother. 1999 Feb;47(6):321-9.


To characterize the interactions between 9.2.27 and melanoma cells more carefully, data on the kinetics of binding, internalization, and degradation of 9.2.27 by SK-MEL-2 cells were collected.
2(0,0,0,2) Details