Protein Information

Name single chain Fv fragments
Synonyms SCFV; Single chain Fv; scFv; single chain Fv fragment; Single chain Fvs; scFvs; single chain Fv fragments

Compound Information

Name MAA
CAS methylarsonic acid

Reference List

PubMed Abstract RScore(About this table)
11156253 Kang N, Hamilton S, Odili J, Wilson G, Kupsch J: In vivo targeting of malignant melanoma by 125Iodine- and 99mTechnetium-labeled single-chain Fv fragments against high molecular weight melanoma-associated antigen. Clin Cancer Res. 2000 Dec;6(12):4921-31.

11(0,0,0,11) Details
9622083 Desai SA, Wang X, Noronha EJ, Kageshita T, Ferrone S: Characterization of human anti-high molecular weight-melanoma-associated antigen single-chain Fv fragments isolated from a phage display antibody library. Cancer Res. 1998 Jun 1;58(11):2417-25.

10(0,0,0,10) Details
10661765 Kang NV, Hamilton S, Sanders R, Wilson GD, Kupsch JM: Efficient in vivo targeting of malignant melanoma by single-chain Fv antibody fragments. Melanoma Res. 1999 Dec;9(6):545-56.

7(0,0,0,7) Details
11839253 Hamilton S, Odili J, Gundogdu O, Wilson GD, Kupsch JM: Improved production by domain inversion of single-chain Fv antibody fragment against high molecular weight proteoglycan for the radioimmunotargeting of melanoma. Hybrid Hybridomics. 2001;20(5-6):351-60.

7(0,0,0,7) Details
9743360 Noronha EJ, Wang X, Desai SA, Kageshita T, Ferrone S: Limited diversity of human scFv fragments isolated by panning a synthetic phage-display scFv library with cultured human melanoma cells. J Immunol. 1998 Sep 15;161(6):2968-76.

6(0,0,0,6) Details
10400790 Martin F, Neil S, Kupsch J, Maurice M, Cosset F, Collins M: Retrovirus targeting by tropism restriction to melanoma cells. J Virol. 1999 Aug;73(8):6923-9.


To target retroviruses to melanomas, we fused a single-chain variable fragment antibody (scFv) directed against the surface glycoprotein high-molecular-weight melanoma-associated antigen (HMW-MAA) to the amphotropic murine leukemia virus envelope.
3(0,0,0,3) Details
10752477 Tordsson JM, Ohlsson LG, Abrahmsen LB, Karlstrom PJ, Lando PA, Brodin TN: Phage-selected primate antibodies fused to superantigens for immunotherapy of malignant melanoma. Cancer Immunol Immunother. 2000 Mar;48(12):691-702.


Several clones producing monoclonal scFv antibody fragments that react with HMW-MAA were identified using melanoma cells and tissue sections for phage selection of a recombinant antibody phage library generated from lymph node mRNA.
2(0,0,0,2) Details
11092052 Abken H, Hombach A, Heuser C, Reinhold U: A novel strategy in the elimination of disseminated melanoma cells: chimeric receptors endow T cells with tumor specificity. Recent Results Cancer Res. 2001;158:249-64.


Cytotoxic T cells grafted with the chimeric anti-HMW-MAA scFv-gamma signaling receptor specifically lyse HMW-MAA-positive melanoma cells in a human leukocyte antigen class I-independent fashion.
1(0,0,0,1) Details