Protein Information

Name melanoma antigens (protein family or complex)
Synonyms Melanoma antigen; Melanoma antigens

Compound Information

Name MAA
CAS methylarsonic acid

Reference List

PubMed Abstract RScore(About this table)
8104570 von Stamm U, Brocker EB, von Depka Prondzinski M, Ruiter DJ, Rumke P, Broding C, Carrel S, Lejeune FJ: Effects of systemic interferon-alpha (IFN-alpha) on the antigenic phenotype of melanoma metastases. Melanoma Res. 1993 Jun;3(3):173-80.


In order to investigate the effects of in vivo treatment with interferon-alpha (IFN-alpha) on melanoma antigens, a clinical EORTC trial (No. 18852) was accompanied by an immunohistological study.
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7939169 Merimsky O, Shoenfeld Y, Chaitchik S, Yecheskel G, Fishman P: Antigens and antibodies in malignant melanoma. . Tumour Biol. 1994;15(4):188-202.


Immunization of melanoma patients with vaccines containing treated melanoma cells or specific melanoma antigens or anti-idiotypic antibodies resulted in an increasing titer of antimelanoma antibodies and regression of the tumor to some extent.
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14679014 Prins RM, Odesa SK, Liau LM: Immunotherapeutic targeting of shared melanoma-associated antigens in a murine glioma model. Cancer Res. 2003 Dec 1;63(23):8487-91.


In this study, we provide evidence that two common murine glioma cell lines (GL26 and GL261) express the melanoma antigens gp100 and tyrosinase-related protein 2 (TRP-2).
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9773250 Merimsky O, Shoenfeld Y, Fishman P: The clinical significance of antityrosinase antibodies in melanoma and related hypopigmentary lesions. Clin Rev Allergy Immunol. 1998 Fall;16(3):227-36.


This observation reflected the possible absorption of antityrosinase antibodies by melanoma antigens, and pointed to the participation of the antibodies in the destruction of normal melanocytes in patients with melanoma, as part of the immune reaction towards this disease.
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