Protein Information

Name glutathione S transferase
Synonyms GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2…

Compound Information

Name MAA
CAS methylarsonic acid

Reference List

PubMed Abstract RScore(About this table)
2872706 Hoshi K, Senda N, Igarashi T, Satoh T, Ueno K, Kitagawa H: Effects of co-administration of monomethylaminoantipyrine with diethylaminoethyl 2,2-diphenylvalerate (SKF 525-A) on gamma-glutamyltranspeptidase, glutathione S-transferase and hepatic drug metabolizing enzyme activities in rats. Res Commun Chem Pathol Pharmacol. 1986 Apr;52(1):71-80.

On the other hand, glutathione S-transferase and gamma-glutamyltranspeptidase (gamma-GTP) activities of rat liver were both induced by repeated administration of MAA in combination with SKF 525-A.
7(0,0,1,2) Details
10471397 Cornett R, James MO, Henderson GN, Cheung J, Shroads AL, Stacpoole PW: Inhibition of glutathione S-transferase zeta and tyrosine metabolism by dichloroacetate: a potential unifying mechanism for its altered biotransformation and toxicity. Biochem Biophys Res Commun. 1999 Sep 7;262(3):752-6.

2(0,0,0,2) Details
16061321 Poon R, Wade M, Valli VE, Chu I: Short-term oral toxicity of butyl ether, ethyl hexyl ether, methyl heptyl ether and 1,6-dimethoxyhexane in male rats and the role of 2-methoxyacetic acid. Toxicology. 2005 Oct 15;214(1-2):99-112.


All four ethers produced hepatic effects at 200mg/kg consisting of mild, adaptive histological changes, increased urinary ascorbic acid output, and elevation in the activities of one or more xenobiotic metabolizing enzymes (benzyloxyresorufin-O-dealkylase, UDP-glucuronosyltransferase, glutathione-S-transferases).
1(0,0,0,1) Details
12678737 Leu TH, Maa MC: The molecular mechanisms for the antitumorigenic effect of curcumin. . Curr Med Chem Anticancer Agents. 2002 May;2(3):357-70.


These included the aryl hydrocarbon receptor, cytochrome P450, glutathione S-transferase, serine/threonine kinases, transcription factors, cyclooxygenase, ornithine decarboxylase, nitric oxide synthase, matrix metalloproteinases and tyrosine kinases.
1(0,0,0,1) Details
3613284 Hoshi K, Senda N, Igarashi T, Satoh T, Ueno K, Kitagawa H: Effects of co-administration of monomethylaminoantipyrine and cobaltous chloride on hepatic glutathione level and glutathione-related enzyme activities in rats. Jpn J Pharmacol. 1987 Apr;43(4):335-9.

Concurrent administration of monomethylaminoantipyrine (MAA) and CoCl2 caused a significant decrease of hepatic reduced glutathione and oxidized glutathione levels.
Furthermore, the increase of glutathione S-transferase activity by combined treatment resulted in the decrease of Se-dependent glutathione peroxidase activity.
1(0,0,0,1) Details