Protein Information

Name IL 6
Synonyms 26 kd protein; B cell differentiation factor; B cell stimulatory factor 2; BSF 2; BSF2; CDF; CTL differentiation factor; HGF…

Compound Information

Name MAA
CAS methylarsonic acid

Reference List

PubMed Abstract RScore(About this table)
18310089 Tang CH, Chuang JY, Fong YC, Maa MC, Way TD, Hung CH: Bone-derived SDF-1 stimulates IL-6 release via CXCR4, ERK and NF-kappaB pathways and promotes osteoclastogenesis in human oral cancer cells. Carcinogenesis. 2008 Aug;29(8):1483-92. Epub 2008 Feb 28.

8(0,0,0,8) Details
9449430 Blom MA, van Twillert MG, de Vries SC, Engels F, Finch CE, Veerhuis R, Eikelenboom P: NSAIDS inhibit the IL-1 beta-induced IL-6 release from human post-mortem astrocytes: the involvement of prostaglandin E2. Brain Res. 1997 Nov 28;777(1-2):210-8.

7(0,0,0,7) Details
9060545 Du Bois JS, Trehu EG, Mier JW, Shapiro L, Epstein M, Klempner M, Dinarello C, Kappler K, Ronayne L, Rand W, Atkins MB: Randomized placebo-controlled clinical trial of high-dose interleukin-2 in combination with a soluble p75 tumor necrosis factor receptor immunoglobulin G chimera in patients with advanced melanoma and renal cell carcinoma. J Clin Oncol. 1997 Mar;15(3):1052-62.


IL-2-induced TNF bioactivity, neutrophil chemotactic defect, and serum IL-6, IL-8, and IL-1 receptor antagonist (IL-1RA) induction were suppressed by rhuTNFR:Fc.
1(0,0,0,1) Details
15472138 Zhong H, Belardinelli L, Maa T, Zeng D: Synergy between A2B adenosine receptors and hypoxia in activating human lung fibroblasts. Am J Respir Cell Mol Biol. 2005 Jan;32(1):2-8. Epub 2004 Oct 7.


Under the normoxic condition, adenosine and its stable analog, 5'-(N-ethylcarboxamido)-adenosine, via activation of A2B adenosine receptors, increased the release of interleukin (IL)-6 by 14-fold and induced the differentiation of human lung fibroblasts to myofibroblasts.
4(0,0,0,4) Details
12855406 Zhong H, Belardinelli L, Maa T, Feoktistov I, Biaggioni I, Zeng D: A (2B) adenosine receptors increase cytokine release by bronchial smooth muscle cells. Am J Respir Cell Mol Biol. 2004 Jan;30(1):118-25. Epub 2003 Jul 10.


NECA increased the release of interleukin-6 and monocyte chemotactic protein-1 proteins with EC50 values of 1.26 +/- 0.25 microM and 0.40 +/- 0.08 microM, respectively, and the maximal folds of induction were 20.8 +/- 1.7- and 6.4 +/- 0.7-fold, respectively.
2(0,0,0,2) Details
8215585 Smit N, Le Poole I, van den Wijngaard R, Tigges A, Westerhof W, Das P: Expression of different immunological markers by cultured human melanocytes. Arch Dermatol Res. 1993;285(6):356-65.


Additionally, we carried out a preliminary study showing that cultured MC also produce IL-1 and IL-6.
1(0,0,0,1) Details
15963921 Watanabe M, Ebina M, Orson FM, Nakamura A, Kubota K, Koinuma D, Akiyama K, Maemondo M, Okouchi S, Tahara M, Matsumoto K, Nakamura T, Nukiwa T: Hepatocyte growth factor gene transfer to alveolar septa for effective suppression of lung fibrosis. Mol Ther. 2005 Jul;12(1):58-67.


The exogenous source of hHGF gene expression increased the endogenous mouse HGF in the lungs and significantly decreased TNF-alpha, IL-6, and collagen synthesis after bleomycin injury.
1(0,0,0,1) Details
8941397 Gershonov E, Granoth R, Tzehoval E, Gaoni Y, Fridkin M: 1-Aminocyclobutanecarboxylic acid derivatives as novel structural elements in bioactive peptides: application to tuftsin analogs. J Med Chem. 1996 Nov 22;39(24):4833-43.


The synthetic methano tuftsin analogs were assayed for their ability to stimulate interleukin-6 (IL-6) secretion by mouse peritoneal macrophages and for their stability in human serum toward enzymatic degradation.
1(0,0,0,1) Details
12946435 Willis MS, Thiele GM, Tuma DJ, Klassen LW: T cell proliferative responses to malondialdehyde-acetaldehyde haptenated protein are scavenger receptor mediated. Int Immunopharmacol. 2003 Oct;3(10-11):1381-99.


IL-4 was absent from the supernatants of T proliferative assays despite a strong IgG1 response in vivo, although the TH2 cytokines IL-6 and IL-10 were expressed.
1(0,0,0,1) Details
9788297 Woon MD, Kaplan HJ, Bora NS: Kinetics of cytokine production in experimental autoimmune anterior uveitis (EAAU). Curr Eye Res. 1998 Oct;17(10):955-61.


The reverse transcription polymerase chain reaction (RT-PCR) was utilized to determine the mRNA expression of IFN-gamma, TNF-alpha, IL-2, IL-4, IL-6 and IL-10.
1(0,0,0,1) Details