Protein Information

Name caspase (protein family or complex)
Synonyms caspase; caspases

Compound Information

Name MAA
CAS methylarsonic acid

Reference List

PubMed Abstract RScore(About this table)
12504796 Garcia-Martinez JM, Fresno Vara JA, Lastres P, Bernabeu C, Betes PO, Martin-Perez J: Effect of metamizol on promyelocytic and terminally differentiated granulocytic cells. Biochem Pharmacol. 2003 Jan 15;65(2):209-17.


Again, the HL60 promyelocytes were more sensitive to apoptosis than granulocytic differentiated cells, as measured by the percentage of sub-G (1) cells detected by flow cytometry and by determination of caspase activity as a function of poly (ADP-ribose) polymerase cleavage.
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18179559 Bagchi G, Waxman DJ: Toxicity of ethylene glycol monomethyl ether: impact on testicular gene expression. Int J Androl. 2008 Apr;31(2):269-74. Epub 2007 Dec 30.


Oxidative stress in spermatocytes exposed to MAA triggers mitochondrial release of cytochrome C, activation of caspases and ultimately apoptosis.
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15182728 Willis MS, Klassen LW, Carlson DL, Brouse CF, Thiele GM: Malondialdehyde-acetaldehyde haptenated protein binds macrophage scavenger receptor (s) and induces lysosomal damage. Int Immunopharmacol. 2004 Jul;4(7):885-99.


Moreover, MAA-haptenated proteins are demonstrated to be associated with a rapid dose-dependent disruption in lysosomal integrity, resulting in leakage and caspase activation.
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16179866 Kamei T, Inui M, Nakase M, Nakamura S, Okumura K, Hiramoto K, Tagawa T: Experimental therapy using interferon-gamma and anti-Fas antibody against oral malignant melanoma cells. Melanoma Res. 2005 Oct;15(5):393-400.


Moreover, inhibition of IFN-gamma/CH-11-induced apoptosis with a general caspase inhibitor (benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone) reduced cell death significantly in vitro.
1(0,0,0,1) Details