Protein Information

Name interferon (protein family or complex)
Synonyms Interferon

Compound Information

Name MAA
CAS methylarsonic acid

Reference List

PubMed Abstract RScore(About this table)
8104570 von Stamm U, Brocker EB, von Depka Prondzinski M, Ruiter DJ, Rumke P, Broding C, Carrel S, Lejeune FJ: Effects of systemic interferon-alpha (IFN-alpha) on the antigenic phenotype of melanoma metastases. Melanoma Res. 1993 Jun;3(3):173-80.

2(0,0,0,2) Details
1643429 Vlock DR, Toporowicz A, Arnold B: Modulation by interferon alpha and gamma of the expression of a melanoma-associated antigen detected by autologous antibody. Melanoma Res. 1992 Jul;2(2):105-14.

2(0,0,0,2) Details
7506284 Gasparini M, Zampino MG, Maffioli L, De Braud F, Bombardieri E, Buraggi GL: Enhancement of in vivo monoclonal antibody targeting with recombinant interferon and cytokines. Int J Biol Markers. 1993 Jul-Sep;8(3):160-5.

1(0,0,0,1) Details
6344987 Giacomini P, Ng AK, Kantor RR, Natali PG, Ferrone S: Double determinant immunoassay to measure a human high-molecular-weight melanoma-associated antigen. Cancer Res. 1983 Aug;43(8):3586-90.


Interferon and hyperthermia increase the shedding of the HMW-MAA by melanoma cells.
1(0,0,0,1) Details
2432832 Giacomini P, Gambari R, Barbieri R, Nistico P, Tecce R, Pestka S, Gustafsson K, Natali PG, Fisher PB: Regulation of the antigenic phenotype of human melanoma cells by recombinant interferons. Anticancer Res. 1986 Sep-Oct;6(5):877-84.


Our studies indicate that the effects of interferons on the antigenic phenotype of melanoma cells will vary depending on the type of interferon employed, the antigen monitored and the target cell studied.
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18088244 Hann HW, Han SH, Block TM, Harris M, Maa JF, Fisher RT, Atillasoy E: Symptomatology and health attitudes of chronic hepatitis B patients in the USA. J Viral Hepat. 2008 Jan;15(1):42-51.


Patients were treated either currently or previously with interferon (IFN) described greater symptomatology than those treated without IFN.
1(0,0,0,1) Details
3129542 Murray JL, Stuckey SE, Pillow JK, Rosenblum MG, Gutterman JU: Differential in vitro effects of recombinant alpha-interferon and recombinant gamma-interferon alone or in combination on the expression of melanoma-associated surface antigens. J Biol Response Mod. 1988 Apr;7(2):152-61.


These data demonstrate that the effects of each interferon (IFN) on the expression of melanoma-associated antigens (MAA) are heterogeneous and depend on IFN type and concentration, exposure time, and characteristics of the antigen studied.
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