| Name | CD8 |
|---|---|
| Synonyms | CD8; p32; MAL; CD8A; CD8a antigen; CD8a molecule; LEU2 T lymphocyte antigen; Leu2… |
| Name | MAA |
|---|---|
| CAS | methylarsonic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18628468 | Molenkamp BG, Sluijter BJ, van Leeuwen PA, Santegoets SJ, Meijer S, Wijnands PG, Haanen JB, van den Eertwegh AJ, Scheper RJ, de Gruijl TD: Local administration of PF-3512676 CpG-B instigates tumor-specific CD8+ T-cell reactivity in melanoma patients. Clin Cancer Res. 2008 Jul 15;14(14):4532-42. |
6(0,0,0,6) | Details |
| 7925777 | Maciejewski JP, Hibbs JR, Anderson S, Katevas P, Young NS: Bone marrow and peripheral blood lymphocyte phenotype in patients with bone marrow failure. Exp Hematol. 1994 Oct;22(11):1102-10. We examined severe (sAA) and moderate AA (mAA) patients and compared them to healthy volunteers and patients with myelodysplastic syndrome (MDS). Our study shows that percentages of HLA-DR+ CD8+ lymphocytes and natural killer (NK) cells, CD56+, were elevated in the marrow of AA patients. |
2(0,0,0,2) | Details |
| 8529406 | Kim MC, Kabeer NH, Tandhasetti MT, Kaplan HJ, Bora NS: Immunohistochemical studies on associated antigen (MAA) induced experimental autoimmune anterior uveitis (EAAU). Curr Eye Res. 1995 Aug;14(8):703-10. Immunohistology of the enucleated eyes was performed with monoclonal antibodies W3/25 (CD4), OX-8 (CD8), ED2 (macrophage), OX-33 (B cell), OX-6 (Ia), IA29 (ICAM-1) and WT.1 (LFA-1). |
2(0,0,0,2) | Details |
| 18829565 | Maciag PC, Seavey MM, Pan ZK, Ferrone S, Paterson Y: Cancer immunotherapy targeting the high molecular weight melanoma-associated antigen protein results in a broad antitumor response and reduction of pericytes in the tumor vasculature. Cancer Res. 2008 Oct 1;68(19):8066-75. Immunization with Lm-LLO-HMW-MAA-C was able to impede the tumor growth of early established B16F10-HMW-MAA tumors in mice and both CD4 (+) and CD8 (+) T cells were required for therapeutic efficacy. |
2(0,0,0,2) | Details |
| 14679014 | Prins RM, Odesa SK, Liau LM: Immunotherapeutic targeting of shared melanoma-associated antigens in a murine glioma model. Cancer Res. 2003 Dec 1;63(23):8487-91. To understand the immunogenicity of murine gliomas to CD8 (+) T cells, we examined the ability of a MAA-specific CTL cell line to lyse the glioma cells, as well as the in vivo expansion of MAA-specific CD8 (+) T cells in animals harboring gliomas. |
2(0,0,0,2) | Details |
| 19884905 | Matta B, Jha P, Bora PS, Bora NS: Antigen-specific tolerance inhibits autoimmune uveitis in pre-sensitized animals by deletion and CD4+CD25+ T-regulatory cells. Immunol Cell Biol. 2010 Feb;88(2):187-96. Epub 2009 Nov 3. The number of cells (total T cells, CD4 (+) T cells and CD8 (+) T cells) undergoing apoptosis dramatically increased in the popliteal lymph nodes (LNs) of the tolerized animals compared with non-tolerized animals. |
2(0,0,0,2) | Details |
| 9524710 | Kim CJ, Cormier J, Roden M, Gritz L, Mazzara GP, Fetsch P, Hijazi Y, Lee KH, Rosenberg SA, Marincola FM: Use of recombinant poxviruses to stimulate anti-melanoma T cell reactivity. Ann Surg Oncol. 1998 Jan-Feb;5(1):64-76. Cytotoxic lymphocytes (CTL) were generated by the stimulation of CD8+ T cells, with DC expressing the recombinant gene. |
2(0,0,0,2) | Details |
| 9220317 | Kim CJ, Prevette T, Cormier J, Overwijk W, Roden M, Restifo NP, Rosenberg SA, Marincola FM: Dendritic cells infected with poxviruses encoding MART-1/Melan A sensitize T lymphocytes in vitro. J Immunother. 1997 Jul;20(4):276-86. In 6/6 HLA A*0201-expressing melanoma patients tested, the virally driven expression of MART-1/Melan A MAA by DC was sufficient to generate CD8+ T lymphocytes that could recognize naturally processed epitopes on tumor cells. |
1(0,0,0,1) | Details |
| 16455987 | Peng L, Ko E, Luo W, Wang X, Shrikant PA, Ferrone S: CD4-dependent potentiation of a high molecular weight-melanoma-associated antigen-specific CTL response elicited in HLA-A2/Kb transgenic mice. J Immunol. 2006 Feb 15;176(4):2307-15. In this report, we show that immunization of HLA-A2/K (b) transgenic mice with HMW-MAA cDNA-transfected syngeneic dendritic cells elicited a CD8 (+) CTL response specific for HMW-MAA peptides with HLA-A2 Ag-binding motifs. |
1(0,0,0,1) | Details |
| 9456433 | Cormier JN, Abati A, Fetsch P, Hijazi YM, Rosenberg SA, Marincola FM, Topalian SL: Comparative analysis of the in vivo expression of tyrosinase, MART-1/Melan-A, and gp100 in metastatic melanoma lesions: implications for immunotherapy. J Immunother. 1998 Jan;21(1):27-31. These Ag can be recognized by CD8+ and, in the case of tyrosinase, CD4+ T cells. |
1(0,0,0,1) | Details |
| 11779404 | Metharom P, Ellem KA, Schmidt C, Wei MQ: Lentiviral vector-mediated tyrosinase-related protein 2 gene transfer to dendritic cells for the therapy of melanoma. Hum Gene Ther. 2001 Dec 10;12(18):2203-13. Administration of mTRP-2 gene-modified DCs (DC-HR' CmT2) to C57BL/6 mice evoked strong protection against tumor challenge, for which the presence of CD4+ and CD8+ cells during both the priming and challenge phase was essential. |
1(0,0,0,1) | Details |
| 10073678 | Alvarez G, Lascurain R, Perez A, Degand P, Montano LF, Martinez-Cairo S, Zenteno E: Relevance of sialoglycoconjugates in murine thymocytes during maturation and selection in the thymus. Immunol Invest. 1999 Jan;28(1):9-18. The immature CD4-CD8- and CD4+CD8+ cortical thymocytes were recognized by SNA, whereas the mature single positive (CD4+ or CD8+) medullary cells, preferentially bound MAA lectin. |
1(0,0,0,1) | Details |
| 18928602 | Chen C, Wei J, Li YF, Huang SL, Fang JP, Zhou DH, Xue HM, Huang K: [Analysis of lymphocyte immune abnormality in 52 cases of children idiopathic aplastic anemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Oct;16(5):1091-5. The levels of CD3 (+) CD8 (+) T cells in SAA group and MAA group were significantly higher than those in controls (p < 0.05). |
1(0,0,0,1) | Details |
| 14502218 | Okada N, Masunaga Y, Okada Y, Mizuguchi H, Iiyama S, Mori N, Sasaki A, Nakagawa S, Mayumi T, Hayakawa T, Fujita T, Yamamoto A: Dendritic cells transduced with gp100 gene by RGD fiber-mutant adenovirus vectors are highly efficacious in generating anti-B16BL6 melanoma immunity in mice. Gene Ther. 2003 Oct;10(22):1891-902. Furthermore, in vivo depletion analysis demonstrated that CD8 (+) CTLs and NK cells were the predominant effector cells responsible for the anti-B16BL6 immunity induced by vaccination with AdRGD-gp100/mBM-DCs, and that helper function of CD4 (+) T cells was necessary for sufficiently eliciting effector activity. These findings clearly revealed that highly efficient MAA gene transduction to DCs by AdRGD could greatly improve the efficacy of DC-based immunotherapy against melanoma. |
1(0,0,0,1) | Details |
| 9331282 | Bora NS, Woon MD, Tandhasetti MT, Cirrito TP, Kaplan HJ: Induction of experimental autoimmune anterior uveitis by a self-antigen: complex without adjuvant. Invest Ophthalmol Vis Sci. 1997 Sep;38(10):2171-5. Adoptive transfer of CD4+ and CD8+ T cells was performed to investigate the pathogenesis of EAAU. |
1(0,0,0,1) | Details |
| 19134253 | Qiao XH, Xie XT, Jiang SY, Shi W, Li W, Zhou JJ: [Natural history of moderate aplastic anemia in children and effects of immunosuppressive therapy]. Zhonghua Er Ke Za Zhi. 2008 Dec;46(12):909-13. The level of CD4 (+), NK cell ratio decreased but the level of CD8 (+) cell increased in MAA children before the treatment. |
1(0,0,0,1) | Details |
| 8081557 | Kim TS, Cohen EP: Immunization of mice with allogeneic fibroblasts genetically modified for interleukin-2-secretion and expression of melanoma-associated antigens stimulate predetermined classes of anti-melanoma effector cells. J Immunother Emphasis Tumor Immunol. 1994 Jul;16(1):24-35. The data indicate that both Lyt-2.2+ (CD8+) and natural killer/lymphokine-activated killer (NK/LAK) cells with anti-melanoma cytotoxicity were predominant in mice immunized with RLBA-IL-2 cells. |
1(0,0,0,1) | Details |
| 11449353 | Benlalam H, Labarriere N, Linard B, Derre L, Diez E, Pandolfino MC, Bonneville M, Jotereau F: Comprehensive analysis of the frequency of recognition of melanoma-associated antigen (MAA) by CD8 melanoma infiltrating lymphocytes (TIL): implications for immunotherapy. Eur J Immunol. 2001 Jul;31(7):2007-15. |
1(0,0,0,1) | Details |
| 1835714 | Radrizzani M, Benedetti B, Castelli C, Longo A, Ferrara GB, Herlyn M, Parmiani G, Fossati G: Human allogeneic melanoma-reactive T-helper lymphocyte clones: functional analysis of lymphocyte-melanoma interactions. Int J Cancer. 1991 Dec 2;49(6):823-30. The 55 clones tested displayed a CD3+, CD4+, CD8-, T-cell receptor (TCR) alpha/beta+, gamma/delta- phenotype. |
1(0,0,0,1) | Details |