Protein Information

Name IL 1
Synonyms Catabolin; IL 1; IL 1 beta; IL 1B; IL1 beta; IL1B; IL1F2; Interleukin 1…

Compound Information

Name MAA
CAS methylarsonic acid

Reference List

PubMed Abstract RScore(About this table)
9449430 Blom MA, van Twillert MG, de Vries SC, Engels F, Finch CE, Veerhuis R, Eikelenboom P: NSAIDS inhibit the IL-1 beta-induced IL-6 release from human post-mortem astrocytes: the involvement of prostaglandin E2. Brain Res. 1997 Nov 28;777(1-2):210-8.

5(0,0,0,5) Details
11008078 Aiba M, Takeyoshi I, Sunose Y, Iwazaki S, Tsutsumi H, Ohwada S, Tomizawa N, Oriuchi N, Matsumoto K, Morishita Y: FR167653 ameliorates pulmonary damage in ischemia-reperfusion injury in a canine lung transplantation model. J Heart Lung Transplant. 2000 Sep;19(9):879-86.


BACKGROUND: Interleukin (IL)-1 and tumor necrosis factor-alpha (TNF-alpha) are recognized as important factors in ischemia-reperfusion (I/R) injury.
3(0,0,0,3) Details
9060545 Du Bois JS, Trehu EG, Mier JW, Shapiro L, Epstein M, Klempner M, Dinarello C, Kappler K, Ronayne L, Rand W, Atkins MB: Randomized placebo-controlled clinical trial of high-dose interleukin-2 in combination with a soluble p75 tumor necrosis factor receptor immunoglobulin G chimera in patients with advanced melanoma and renal cell carcinoma. J Clin Oncol. 1997 Mar;15(3):1052-62.


IL-2-induced TNF bioactivity, neutrophil chemotactic defect, and serum IL-6, IL-8, and IL-1 receptor antagonist (IL-1RA) induction were suppressed by rhuTNFR:Fc.
1(0,0,0,1) Details
8215585 Smit N, Le Poole I, van den Wijngaard R, Tigges A, Westerhof W, Das P: Expression of different immunological markers by cultured human melanocytes. Arch Dermatol Res. 1993;285(6):356-65.


All MC lines, including the MC-a and the melanoma lines, showed expression of MHC class I, IL-1, IL-2, ICAM-1 and the MAA, NKI-Beteb, during all passages tested.
2(0,0,0,2) Details
18926302 Basler T, Geffers R, Weiss S, Valentin-Weigand P, Goethe R: Mycobacterium avium subspecies induce differential expression of pro-inflammatory mediators in a murine macrophage model: evidence for enhanced pathogenicity of Mycobacterium avium subspecies paratuberculosis. Immunobiology. 2008;213(9-10):879-88. Epub 2008 Sep 2.


Among these were the genes for IL-1beta, IL-1alpha, CXCL2, PTGS2 (COX2), lipocalin (LCN2) and TNF, which are important pro-inflammatory factors.
1(0,0,0,1) Details
3262428 Cordiali-Fei P, Mottolese M, Tecce R, Natali P, Ferrone S: Accessory cell function of human melanoma cells in mitogen-induced T cell proliferation. Cell Immunol. 1988 Oct 1;116(1):149-62.


These results suggest that PHA-induced proliferation of T cells in the presence of melanoma cells can bypass the requirement for IL-1 or utilizes factors other than IL-1.
1(0,0,0,1) Details
1835714 Radrizzani M, Benedetti B, Castelli C, Longo A, Ferrara GB, Herlyn M, Parmiani G, Fossati G: Human allogeneic melanoma-reactive T-helper lymphocyte clones: functional analysis of lymphocyte-melanoma interactions. Int J Cancer. 1991 Dec 2;49(6):823-30.


Lymphocyte clones were isolated from CD4+ peripheral-blood lymphocytes (PBL) of melanoma (Me) patient 9923 (HLA-DR7, DQw2, w6), co-cultured for 30 days with autologous accessory cells, allogeneic Me (Me 1811) (HLA-DR7, DQw1, w2), IL-1 beta (2 U/ml) and IL-2 (15 IU/ml).
1(0,0,0,1) Details