Protein Information

Name protein kinase C (protein family or complex)
Synonyms Protein kinase C; PKC

Compound Information

Name MAA
CAS methylarsonic acid

Reference List

PubMed Abstract RScore(About this table)
11839459 Wyatt TA, Kharbanda KK, Tuma DJ, Sisson JH: Malondialdehyde-acetaldehyde-adducted bovine serum albumin activates protein kinase C and stimulates interleukin-8 release in bovine bronchial epithelial cells. Alcohol. 2001 Nov;25(3):159-66.

4(0,0,0,4) Details
11853706 Kharbanda KK, Shubert KA, Wyatt TA, Sorrell MF, Tuma DJ: Effect of malondialdehyde-acetaldehyde-protein adducts on the protein kinase C-dependent secretion of urokinase-type plasminogen activator in hepatic stellate cells. Biochem Pharmacol. 2002 Feb 1;63(3):553-62.

2(0,0,0,2) Details
11391074 Thiele GM, Worrall S, Tuma DJ, Klassen LW, Wyatt TA, Nagata N: The chemistry and biological effects of malondialdehyde-acetaldehyde adducts. Alcohol Clin Exp Res. 2001 May;25(5 Suppl ISBRA):218S-224S.


Thiele; (5) MAA-adducted bovine serum albumin activates protein kinase C and stimulates interleukin-8 release in bovine bronchial epithelial cells, by Todd A.
1(0,0,0,1) Details
16257351 Wyatt TA, Kharbanda KK, Tuma DJ, Sisson JH, Spurzem JR: Malondialdehyde-acetaldehyde adducts decrease bronchial epithelial wound repair. Alcohol. 2005 May;36(1):31-40.


Previously, we have shown that malondialdehyde, an inflammation product of lipid peroxidation, and acetaldehyde, a component of both ethanol metabolism and cigarette smoke, form protein adducts that stimulate protein kinase C (PKC) activation in bronchial epithelial cells.
1(0,0,0,1) Details
9169075 Li LH, Wine RN, Miller DS, Reece JM, Smith M, Chapin RE: Protection against methoxyacetic-acid-induced spermatocyte apoptosis with calcium channel blockers in cultured rat seminiferous tubules: possible mechanisms. Toxicol Appl Pharmacol. 1997 May;144(1):105-19.


We postulate alternate mechanisms based on stabilization of cells membranes, or interactions with calmodulin or protein kinase C.
1(0,0,0,1) Details