| Name | thioredoxin |
|---|---|
| Synonyms | ADF; TRX 1; TRX1; ATL derived factor; SASP; Surface associated sulphydryl protein; TRDX; TRX… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 6114827 | Anders MW, Ratnayake JH, Hanna PE, Fuchs JA: Thioredoxin-dependent sulfoxide reduction by rat renal cytosol. . Drug Metab Dispos. 1981 Jul-Aug;9(4):307-10. Furthermore, disulfides [insulin, and 5,5'-dithiobis (2-nitrobenzoic acid)] known to interact with thioredoxin-dependent enzyme systems inhibited sulindac reduction, as did sodium arsenite, a known inhibitor of thioredoxin reductase. |
34(0,1,1,4) | Details |
| 2719637 | Flamigni F, Marmiroli S, Caldarera CM, Guarnieri C: Involvement of thiol transferase- and thioredoxin-dependent systems in the protection of 'essential' thiol groups of ornithine decarboxylase. Biochem J. 1989 Apr 1;259(1):111-5. In an attempt to investigate the physiological role of the 'essential' thiol group (s) of ODC, erythroleukaemia cells were incubated with NN-bis-(2-chloroethyl)-N'-nitrosourea, t-butyl hydroperoxide and vinblastine, which are known to increase the cellular /GSH ratio, an inhibitor of thioredoxin reductase, and sodium arsenite, a strong inhibitor of the ODC-re-activating factors. |
3(0,0,0,3) | Details |
| 19121333 | Bardullas U, Limon-Pacheco JH, Giordano M, Carrizales L, Mendoza-Trejo MS, Rodriguez VM: Chronic low-level arsenic exposure causes gender-specific alterations in locomotor activity, dopaminergic systems, and thioredoxin expression in mice. Toxicol Appl Pharmacol. 2009 Sep 1;239(2):169-77. Epub 2008 Dec 14. |
2(0,0,0,2) | Details |
| 12519079 | Chang KN, Lee TC, Tam MF, Chen YC, Lee LW, Lee SY, Lin PJ, Huang RN: Identification of galectin I and thioredoxin peroxidase II as two arsenic-binding proteins in Chinese hamster ovary cells. Biochem J. 2003 Apr 15;371(Pt 2):495-503. The GST-P protein has been previously shown to facilitate the excretion of sodium arsenite [As (III)] from SA7 cells. |
2(0,0,0,2) | Details |
| 12076508 | Hu Y, Jin X, Snow ET: Effect of arsenic on transcription factor AP-1 and NF-kappaB DNA binding activity and related gene expression. Toxicol Lett. 2002 Jul 7;133(1):33-45. Both acute (24 h) and chronic (10-20 week) exposure of human fibroblast cells to low dose sodium arsenite (As (III)) significantly affects activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) DNA binding activity. Short-term treatment with 0.1-5 microM As (III) up-regulates expression of c-Fos and c-Jun and the redox regulators, thioredoxin (Trx) and Redox factor-1 (Ref-1) and activates both AP-1 and NF-kappa B binding. |
1(0,0,0,1) | Details |
| 18629308 | Endo H, Sugioka Y, Nakagi Y, Saijo Y, Yoshida T: A novel role of the NRF2 transcription factor in the regulation of arsenite-mediated keratin 16 gene expression in human keratinocytes. Environ Health Perspect. 2008 Jul;116(7):873-9. BACKGROUND: Inorganic sodium arsenite (iAs) is a ubiquitous environmental contaminant and is associated with an increased risk of skin hyperkeratosis and cancer. |
0(0,0,0,0) | Details |
| 9027754 | Brown DM, Upcroft JA, Upcroft P: A thioredoxin reductase-class of disulphide reductase in the protozoan parasite Giardia duodenalis. Mol Biochem Parasitol. 1996 Dec 20;83(2):211-20. The sulphydryl-active compounds, N-ethylmaleimide, sodium arsenite and Zn2+ ions, strongly inhibited the enzyme suggesting that a thiol component forms part of the active site. |
0(0,0,0,0) | Details |