Protein Information

Name interleukin 1 alpha
Synonyms Hematopoietin 1; IL 1 alpha; IL 1A; IL1; IL1 alpha; IL1A; IL1F1; Interleukin 1 alpha…

Compound Information

Name sodium arsenite
CAS sodium arsenenite

Reference List

PubMed Abstract RScore(About this table)
17879257 Perez DS, Handa RJ, Yang RS, Campain JA: Gene expression changes associated with altered growth and differentiation in benzo [a] pyrene or arsenic exposed normal human epidermal keratinocytes. J Appl Toxicol. 2008 May;28(4):491-508.


These studies confirmed increased mRNA levels in NHEK by BaP of alpha-integrin binding protein 63 (AIBP63) (2.48-fold), retinoic acid- and interferon-inducible protein (IFIT5) (2.74-fold), interleukin-1 alpha (IL1A) (2.64-fold), interleukin-1 beta (IL1B) (2.84-fold) and Ras guanyl releasing protein 1 (RASGRP1) (3.14-fold).
1(0,0,0,1) Details
7541446 Satoh J, Kim SU: Cytokines and growth factors induce HSP27 phosphorylation in human astrocytes. J Neuropathol Exp Neurol. 1995 Jul;54(4):504-12.

The level of HSP27 phosphorylation was elevated greatly after a 30 minute exposure to heat shock, sodium arsenite, interleukin-1 (IL-1 alpha and IL-1 beta), and tumor necrosis factor-alpha (TNF-alpha) with an increased expression of a diphosphorylated "c" isoform.
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7735982 Lappas GD, Karl IE, Hotchkiss RS: Effect of ethanol and sodium arsenite on HSP-72 formation and on survival in a murine endotoxin model. Shock. 1994 Jul;2(1):34-9; discussion 40.

Although the mechanism by which hyperthermia protects is unknown, two possible etiologies are induction of HSPs and/or production of cytokines, interleukin-1 alpha (IL-1 alpha) or tumor necrosis factor-alpha (TNF-alpha).
1(0,0,0,1) Details