| Name | AP 1 (protein family or complex) |
|---|---|
| Synonyms | AP 1; AP 1 complex; AP1; Adapter related protein complex 1 |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9535875 | Elbirt KK, Whitmarsh AJ, Davis RJ, Bonkovsky HL: Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. J Biol Chem. 1998 Apr 10;273(15):8922-31. Involvement of an AP-1 site in arsenite induction of heme oxygenase-1 gene expression was studied. |
2(0,0,0,2) | Details |
| 17070520 | Ivanov VN, Hei TK: Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression. Exp Cell Res. 2006 Dec 10;312(20):4120-38. Epub 2006 Sep 28. AP-1/cJun, NF-kappaB and STAT3 transcription factors control expression of numerous genes, which regulate critical cell functions including proliferation, survival and apoptosis. |
1(0,0,0,1) | Details |
| 15276422 | Luster MI, Simeonova PP: Arsenic and urinary bladder cell proliferation. Toxicol Appl Pharmacol. 2004 Aug 1;198(3):419-23. We have employed in vitro and in vivo models to examine the effects of sodium arsenite on the urinary bladder epithelium. Arsenic-induced cell proliferation in the bladder epithelium was correlated with activation of the MAP kinase pathway, leading to extracellular signal-regulated kinase (ERK) kinase activity, AP-1 activation, and expression of AP-1-associated genes involved in cell proliferation. |
1(0,0,0,1) | Details |
| 11693998 | Zeng H: Arsenic suppresses necrosis induced by selenite in human leukemia HL-60 cells. Biol Trace Elem Res. 2001 Oct;83(1):1-15. Similarly, both sodium arsenite (NaAsO2) at 50 microM and arsenate (Na2HAsO4) induce apoptosis at 500 microM and necrosis at higher concentrations (> 50 microM and > 500 microM, respectively) in HL-60 cells. |
0(0,0,0,0) | Details |
| 10933875 | Shan Y, Pepe J, Lu TH, Elbirt KK, Lambrecht RW, Bonkovsky HL: Induction of the heme oxygenase-1 gene by metalloporphyrins. Arch Biochem Biophys. 2000 Aug 15;380(2):219-27. The antioxidant and &bond;SH donor N-acetyl had little effect on the metalloporphyrin-dependent inductions of HO-1, in contrast to its marked inhibitory effect on the sodium arsenite-dependent induction of the HO-1 gene. |
0(0,0,0,0) | Details |
| 10942197 | Lu TH, Shan Y, Pepe J, Lambrecht RW, Bonkovsky HL: Upstream regulatory elements in chick heme oxygenase-1 promoter: a study in primary cultures of chick embryo liver cells. Mol Cell Biochem. 2000 Jun;209(1-2):17-27. Because sodium arsenite is known to cause oxidative stress and because activation of AP-1 proteins has been shown to be a key step in the oxidative stress response pathway, we also explored the possibility that the induction of the cHO-1 gene by sodium arsenite is mediated through oxidative stress pathway (s) by activation of AP-1 proteins. |
233(2,4,5,8) | Details |
| 11248140 | Simeonova PP, Wang S, Kashon ML, Kommineni C, Crecelius E, Luster MI: Quantitative relationship between arsenic exposure and AP-1 activity in mouse urinary bladder epithelium. Toxicol Sci. 2001 Apr;60(2):279-84. Marked AP-1 DNA-binding activity only occurred at exposure levels of sodium arsenite above 20 microg/ml, where histopathological changes and accumulation of arsenic in the urinary bladder epithelium occurred. |
86(1,1,1,6) | Details |
| 10600159 | Shan Y, Lambrecht RW, Hong Lu T, Bonkovsky HL: Effects of phenylarsine oxide on expression of heme oxygenase-1 reporter constructs in transiently transfected cultures of chick embryo liver cells. Arch Biochem Biophys. 1999 Dec 15;372(2):224-9. Using heme oxygenase-1 promoter/reporter gene constructs, we have previously reported that the sodium arsenite-mediated induction of heme oxygenase-1 in chick embryo liver cells and chicken hepatoma (LMH) cells involves an AP-1 element. |
85(1,1,1,5) | Details |
| 12076508 | Hu Y, Jin X, Snow ET: Effect of arsenic on transcription factor AP-1 and NF-kappaB DNA binding activity and related gene expression. Toxicol Lett. 2002 Jul 7;133(1):33-45. Both acute (24 h) and chronic (10-20 week) exposure of human fibroblast cells to low dose sodium arsenite (As (III)) significantly affects activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) DNA binding activity. |
35(0,1,1,5) | Details |
| 11353137 | Wijeweera JB, Gandolfi AJ, Parrish A, Lantz RC: Sodium arsenite enhances AP-1 and NFkappaB DNA binding and induces stress protein expression in precision-cut rat lung slices. Toxicol Sci. 2001 Jun;61(2):283-94. |
34(0,1,1,4) | Details |
| 14962100 | Liao WT, Chang KL, Yu CL, Chen GS, Chang LW, Yu HS: Arsenic induces human keratinocyte apoptosis by the FAS/FAS ligand pathway, which correlates with alterations in nuclear factor-kappa B and activator protein-1 activity. J Invest Dermatol. 2004 Jan;122(1):125-9. To investigate the mechanism of arsenic-induced apoptosis and related alterations in NF-kappa B and AP-1 activity, we exposed cultured human foreskin keratinocytes to different concentrations of sodium arsenite. |
34(0,1,1,4) | Details |
| 14523996 | Hershko DD, Robb BW, Luo GJ, Hungness ES, Hasselgren PO: Sodium arsenite downregulates transcriptional activity of AP-1 and CRE binding proteins in IL-1beta-treated Caco-2 cells by increasing the expression of the transcriptional repressor CREMalpha. J Cell Biochem. 2003 Oct 15;90(3):627-40. |
33(0,1,1,3) | Details |
| 18404528 | Harada H, Sugimoto R, Watanabe A, Taketani S, Okada K, Warabi E, Siow R, Itoh K, Yamamoto M, Ishii T: Differential roles for Nrf2 and AP-1 in upregulation of HO-1 expression by arsenite in murine embryonic fibroblasts. Free Radic Res. 2008 Apr;42(4):297-304. Heme oxygenase-1 (HO-1) is markedly upregulated by sodium arsenite and previous studies implicated the transcriptional enhancers Nrf2 and AP-1 in arsenite-induced ho-1 gene expression in murine cells. |
8(0,0,1,3) | Details |
| 15849723 | Felix K, Manna SK, Wise K, Barr J, Ramesh GT: Low levels of arsenite activates nuclear factor-kappaB and activator protein-1 in immortalized mesencephalic cells. J Biochem Mol Toxicol. 2005 Mar-Apr;19(2):67-77. These mesencephalic cells were treated with low concentrations of sodium arsenite (0.1, 0.5, 1, 5, and 10 microM) and incubated for different periods of time (0-4 h). Arsenite, in a dose-dependent manner, induced generation of reactive species (ROS) and activation of early transcription factors such as nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) as shown by electro mobility shift assay. |
4(0,0,0,4) | Details |
| 9837857 | Hartsfield CL, Alam J, Choi AM: Transcriptional regulation of the heme oxygenase 1 gene by pyrrolidine dithiocarbamate. FASEB J. 1998 Dec;12(15):1675-82. Heme oxygenase 1 (HO-1), a stress response protein, is highly induced in response to various agents causing oxidative stress including ultraviolet irradiation, sodium arsenite, hyperoxia, and depletors. Mutational analyses of this enhancer showed that the activator protein 1 (AP-1) regulatory element is crucial for PDTC-induced HO-1 gene transcription. |
3(0,0,0,3) | Details |
| 10910055 | Simeonova PP, Wang S, Toriuma W, Kommineni V, Matheson J, Unimye N, Kayama F, Harki D, Ding M, Vallyathan V, Luster MI: Arsenic mediates cell proliferation and gene expression in the bladder epithelium: association with activating protein-1 transactivation. Cancer Res. 2000 Jul 1;60(13):3445-53. In the current studies, we demonstrate that mice exposed to 0.01% sodium arsenite in drinking water develop hyperplasia of the bladder urothelium within 4 weeks of exposure. This was accompanied by the accumulation of inorganic trivalent arsenic, and to a lesser extent dimethylarsinic acid, in bladder tissue, as well as a persistent increase in DNA binding of the activating protein (AP)-1 transcription factor. |
3(0,0,0,3) | Details |
| 20071421 | Shinkai Y, Yamamoto C, Kaji T: Lead induces the expression of endoplasmic reticulum chaperones GRP78 and GRP94 in vascular endothelial cells via the JNK-AP-1 pathway. Toxicol Sci. 2010 Apr;114(2):378-86. Epub 2010 Jan 13. Compared with other metal (loid) s, including cadmium zinc and sodium arsenite, lead was found to be the most potent metal to induce these chaperones in endothelial cells. |
3(0,0,0,3) | Details |
| 12637567 | Kietzmann T, Samoylenko A, Immenschuh S: Transcriptional regulation of heme oxygenase-1 gene expression by MAP kinases of the JNK and p38 pathways in primary cultures of rat hepatocytes. J Biol Chem. 2003 May 16;278(20):17927-36. Epub 2003 Mar 11. Heme oxygenase-1 (HO-1) gene expression is induced by various oxidative stress stimuli including sodium arsenite. Electrophoretic mobility shift assays (EMSA) revealed that a CRE/AP-1 element (-668/-654) bound c-Jun, a target of the JNK pathway. |
3(0,0,0,3) | Details |
| 12210719 | Li M, Cai JF, Chiu JF: Arsenic induces oxidative stress and activates stress gene expressions in cultured lung epithelial cells. J Cell Biochem. 2002;87(1):29-38. The activation of AP-1 transcription factors may also play a regulatory role in this process. |
2(0,0,0,2) | Details |
| 10381381 | Masuya Y, Kameshita I, Fujisawa H, Kohno H, Hioki K, Tokunaga R, Taketani S: MAP kinase-independent induction of proto-oncogene c-fos mRNA by hemin in human cells. Biochem Biophys Res Commun. 1999 Jun 24;260(1):289-95. With gel mobility assay, the DNA AP-1 binding activity transiently increased when treating HeLa cells with hemin. |
2(0,0,0,2) | Details |
| 15741166 | Miralem T, Hu Z, Torno MD, Lelli KM, Maines MD: Small interference RNA-mediated gene silencing of human reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells. J Biol Chem. 2005 Apr 29;280(17):17084-92. Epub 2005 Feb 28. It is a zipper (bZip) DNA-binding protein and a regulatory factor for 8/7-bp AP-1-regulated genes, including HO-1 and ATF-2/CREB. Presently, small interference (si) RNA constructs were used to investigate the role of human BVR in sodium arsenite (As)-mediated induction of HO-1 and in cytoprotection against apoptosis. |
1(0,0,0,1) | Details |
| 17938202 | Fung H, Liu P, Demple B: ATF4-dependent oxidative induction of the DNA repair enzyme Ape1 counteracts arsenite cytotoxicity and suppresses arsenite-mediated mutagenesis. Mol Cell Biol. 2007 Dec;27(24):8834-47. Epub 2007 Oct 15. We investigated expression of the essential base excision DNA repair enzyme apurinic endonuclease 1 (Ape1) in response to sodium arsenite. Analysis of the APE1 promoter region revealed an AP-1/CREB binding site essential for arsenite-induced transcriptional activation in both mouse and human cells. |
1(0,0,0,1) | Details |
| 9511760 | Lu TH, Lambrecht RW, Pepe J, Shan Y, Kim T, Bonkovsky HL: Molecular cloning, characterization, and expression of the chicken heme oxygenase-1 gene in transfected primary cultures of chick embryo liver cells. Gene. 1998 Jan 30;207(2):177-86. These include AP-1, AP-2, NF-kB, C/EBP, c-Myc and a metal-responding element identified in the promoter region, and two Sp-1 elements in intron 1. Transient expression studies in transfected primary cultures of chick embryo liver cells showed that a CAT reporter gene construct containing 2.8 kb of the cHO-1 promoter region responded to sodium arsenite, H2O2, transition metals and 12-0-tetradecanoylphorbol 13- but not to heme. |
2(0,0,0,2) | Details |
| 11353140 | Liu J, Kadiiska MB, Liu Y, Lu T, Qu W, Waalkes MP: Stress-related gene expression in mice treated with inorganic arsenicals. Toxicol Sci. 2001 Jun;61(2):314-20. Multiprobe RNase protection assay revealed the activation of the c-Jun/AP-1 transcription complex after arsenic treatments. Mice were injected sc with either sodium arsenite [As (III), 100 micromol/kg], arsenate [As (V), 300 micromol/kg], or saline. |
2(0,0,0,2) | Details |