Protein Information

Name endothelin 1
Synonyms EDN 1; EDN1; ET1; Endothelin 1; Endothelin 1 precursor; PPET 1; PPET1; Preproendothelin 1…

Compound Information

Name sodium arsenite
CAS sodium arsenenite

Reference List

PubMed Abstract RScore(About this table)
11862762 Kozawa O, Tokuda H: [Heat shock protein 27 in osteoblasts] . Nippon Yakurigaku Zasshi. 2002 Feb;119(2):89-94.

Chemical stress by sodium arsenite (arsenite) induces HSP27 coupled to the metabolic activity of the arachidonic acid cascade, and the HSP27 induction by arsenite is negatively regulated by activation of protein kinase C (PKC).
On the contrary, physiological regulators of bone such as endothelin-1, prostaglandin F2 alpha (PGF2 alpha), PGD2, and basic fibroblast growth factor (bFGF) induce HSP 27 via protein kinase C (PKC) activation.
1(0,0,0,1) Details
11325585 Chevalier D, Thorin E, Allen BG: Simultaneous measurement of ERK, p38, and JNK MAP kinase cascades in vascular smooth muscle cells. J Pharmacol Toxicol Methods. 2000 Sep-Oct;44(2):429-39.

Activation of the mitogen-activated protein kinase (MAP kinase) pathways in cultured porcine aortic vascular smooth muscle cells (VSMCs) was determined following a 5-min stimulation with endothelin-1 (ET-1), phorbol 12-myristate 13-acetate (PMA), H2O2, or sodium arsenite.
31(0,1,1,1) Details
17608860 Yamaguchi E, Yamanoi A, Ono T, Nagasue N: Experimental investigation of the role of endothelin-1 in idiopathic portal hypertension. J Gastroenterol Hepatol. 2007 Jul;22(7):1134-40.

In a second experiment, B and T lymphocytes and monocyte-derived macrophages cultured from healthy human peripheral blood were stimulated with sodium arsenite, sodium arsenate, lipopolysaccharide and interferon-gamma.
8(0,0,0,8) Details