| Name | caspase 3 |
|---|---|
| Synonyms | Apopain; CASP 3; CASP3; CPP 32; CPP32; CPP32B; Caspase 3; Caspase 3 precursor… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17681577 | Lin AM, Chao PL, Fang SF, Chi CW, Yang CH: Endoplasmic reticulum stress is involved in arsenite-induced oxidative injury in rat brain. Toxicol Appl Pharmacol. 2007 Oct 15;224(2):138-46. Epub 2007 Jul 3. For mitochondrial activation, cytosolic cytochrome c and caspase-3 levels were elevated in the arsenite-infused SN. The mechanism underlying sodium arsenite (arsenite)-induced neurotoxicity was investigated in rat brain. |
1(0,0,0,1) | Details |
| 12472888 | Fauconneau B, Petegnief V, Sanfeliu C, Piriou A, Planas AM: Induction of heat shock proteins (HSPs) by sodium arsenite in cultured astrocytes and reduction of peroxide-induced cell death. J Neurochem. 2002 Dec;83(6):1338-48. TdT-mediated nick-end labelling (TUNEL) reaction and caspase-3 activation. |
1(0,0,0,1) | Details |
| 19429265 | Das J, Ghosh J, Manna P, Sinha M, Sil PC: protects rat testes against NaAsO (2)-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways. Toxicol Lett. 2009 Jun 22;187(3):201-10. Epub 2009 Mar 14. In this study, we report that As administration (in the form of NaAsO (2) at a dose of 10mg/kg body weight for 2 days, orally) induces apoptosis in testicular tissue of the experimental rats by the activation of caspase-3 and reciprocal regulation of Bcl-2/Bad with the concomitant reduction of mitochondrial membrane potential and increased level of cytosolic cytochrome C. |
1(0,0,0,1) | Details |
| 13129816 | Yeh JY, Cheng LC, Liang YC, Ou BR: Modulation of the arsenic effects on cytotoxicity, viability, and cell cycle in porcine endothelial cells by Endothelium. 2003;10(3):127-39. MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium assay indicated that arsenic trioxide (As (2) O (3)) and sodium arsenite (NaAsO (2)) showed similar cytotoxicity, whereas arsenate (Na (2) HAsO (4)) did not show cytotoxicity in PAECs. As (2) O (3)-induced apoptosis was associated with upregulation of p53 and caspase 3, whereas NaAsO (2)-induced apoptosis was associated with p53 upregulation. |
1(0,0,0,1) | Details |
| 18715270 | Lin AM, Feng SF, Chao PL, Yang CH: inhibits arsenite-induced peripheral neurotoxicity. J Pineal Res. 2009 Jan;46(1):64-70. Epub 2008 Aug 18. At the same time, inhibited arsenite-induced activation of caspase 3 in the treated DRG explants. In this study, the effect of on sodium arsenite (arsenite)-induced peripheral neurotoxicity was investigated using dorsal root ganglion (DRG) explants. |
1(0,0,0,1) | Details |
| 16079067 | Wu F, Burns FJ, Zhang R, Uddin AN, Rossman TG: Arsenite-induced alterations of DNA photodamage repair and apoptosis after solar-simulation UVR in mouse keratinocytes in vitro. Environ Health Perspect. 2005 Aug;113(8):983-6. The keratinocytes were treated with different concentrations of sodium arsenite (0.0, 2.5, 5.0 microM) for 24 hr and then were immediately irradiated with a single dose of 0.30 kJ/m2 UVR. Arsenite decreased the UVR-induced caspase-3/7 activity in parallel with the inhibition of apoptosis. |
1(0,0,0,1) | Details |
| 18501396 | McNeely SC, Taylor BF, States JC: Mitotic arrest-associated apoptosis induced by sodium arsenite in A375 melanoma cells is BUBR1-dependent. Toxicol Appl Pharmacol. 2008 Aug 15;231(1):61-7. Epub 2008 Apr 9. Mitotic arrest resulted in apoptosis as indicated by colocalization of mitotic phospho-Histone H3 with active caspase 3. |
1(0,0,0,1) | Details |
| 12676792 | Mathas S, Lietz A, Janz M, Hinz M, Jundt F, Scheidereit C, Bommert K, Dorken B: Inhibition of NF-kappaB essentially contributes to arsenic-induced apoptosis. Blood. 2003 Aug 1;102(3):1028-34. Epub 2003 Apr 3. In these cell lines, apoptosis was blocked by inhibition of caspase-8 and caspase-3-like activity. |
1(0,0,0,1) | Details |
| 15737492 | Ramanathan K, Anusuyadevi M, Shila S, Panneerselvam C: and as potent modulators of apoptosis on arsenic induced toxicity in rats. Toxicol Lett. 2005 Apr 10;156(2):297-306. Epub 2005 Jan 13. The present work was conducted to evaluate the regulatory effect exerted by and upon the apoptotic process, which can be assessed by the presence of cells with apoptosis associated DNA breaks and characterize the role of TNF-alpha and caspase-3 in rats intoxicated with arsenic. |
1(0,0,0,1) | Details |
| 11813266 | Chou RH, Huang H: Sodium arsenite suppresses human papillomavirus-16 E6 gene and enhances apoptosis in E6-transfected human lymphoblastoid cells. J Cell Biochem. 2002;84(3):615-24. After arsenite treatment, TK6-E6 cells showed more sub-G1 apoptosis, activated caspase-3/CPP32 fragment, DNA ladder, and less viability than parental TK6 cells, indicating that arsenite enhanced apoptosis in E6-transfected TK6 cells. |
1(0,0,0,1) | Details |
| 16251481 | Sidhu JS, Ponce RA, Vredevoogd MA, Yu X, Gribble E, Hong SW, Schneider E, Faustman EM: Cell cycle inhibition by sodium arsenite in primary embryonic rat midbrain neuroepithelial cells. Toxicol Sci. 2006 Feb;89(2):475-84. Epub 2005 Oct 26. |
0(0,0,0,0) | Details |
| 10652248 | Mirkes PE, Little SA: Cytochrome c release from mitochondria of early postimplantation murine embryos exposed to 4-hydroperoxycyclophosphamide, heat shock, and staurosporine. Toxicol Appl Pharmacol. 2000 Feb 1;162(3):197-206. Previously, we showed that the cell death induced in day 9 mouse embryos by three teratogens, hyperthermia (HS), 4-hydroperoxycyclophosphamide (4-CP), and sodium arsenite (As), is apoptotic in nature involving the activation of caspase-3, cleavage of poly (ADP- polymerase (PARP), and DNA fragmentation. |
84(1,1,1,4) | Details |
| 15130612 | Greenlee AR, Kronenwetter-Koepel TA, Kaiser SJ, Ellis TM, Liu K: Combined effects of Matrigel and growth factors on maintaining undifferentiated murine embryonic stem cells for embryotoxicity testing. Toxicol In Vitro. 2004 Aug;18(4):543-53. Early-passage cells showed dose-responsive caspase-3 activation following exposure to sodium arsenite, whereas caspase-3 activation of late-passage cells dropped to background levels at toxicant dosages above 50 ppb. |
83(1,1,1,3) | Details |
| 10200514 | Mirkes PE, Little SA: Teratogen-induced cell death in postimplantation mouse embryos: differential tissue sensitivity and hallmarks of apoptosis. Cell Death Differ. 1998 Jul;5(7):592-600. We show that three teratogens, hyperthermia, cyclophosphamide and sodium arsenite induce an increase in cell death in day 9.0 mouse embryos with concurrent induction of DNA fragmentation, activation of caspase-3 and the cleavage of poly (ADP- polymerase (PARP). |
82(1,1,1,2) | Details |
| 16497974 | Che XF, Zheng CL, Owatari S, Mutoh M, Gotanda T, Jeung HC, Furukawa T, Ikeda R, Yamamoto M, Haraguchi M, Arima N, Akiyama S: Overexpression of survivin in primary ATL cells and sodium arsenite induces apoptosis by down-regulating survivin expression in ATL cell lines. Blood. 2006 Jun 15;107(12):4880-7. Epub 2006 Feb 23. Sodium arsenite was shown to down-regulate the expression of survivin at both the protein and RNA levels in a time- and dose-dependent manner, thus inhibiting cell growth, inducing apoptosis, and enhancing the caspase-3 activity in ATL cells. |
81(1,1,1,1) | Details |
| 15713546 | Greenlee AR, Kronenwetter-Koepel TA, Kaiser SJ, Liu K: Comparison of Matrigel and gelatin substrata for feeder-free culture of undifferentiated mouse embryonic stem cells for toxicity testing. Toxicol In Vitro. 2005 Apr;19(3):389-97. Epub 2005 Jan 21. In other comparisons, however, Matrigel supported significantly higher synthesis of alkaline phosphatase (7.7x10 (-3)+/-0.8 vs 6.6x10 (-3)+/-0.8 units/liter/cell, respectively, P=0.012), overall expression of activated caspase-3 following exposure to 5, 10, 50, 100 and 500 parts per billion (ppb) sodium arsenite (P <0.0001), and percent development to beating cardiomyocytes at P7 (P=0.01). |
32(0,1,1,2) | Details |
| 17849503 | Watcharasit P, Thiantanawat A, Satayavivad J: GSK3 promotes arsenite-induced apoptosis via facilitation of mitochondria disruption. J Appl Toxicol. 2008 May;28(4):466-74. Investigation of the involvement of GSK3 in arsenite-induced apoptosis demonstrated that arsenite induced apoptosis in SH-SY5Y human neuroblastoma cells, activating the executioner caspase-3 which caused cleavage of poly-ADP -polymerase (PARP). |
2(0,0,0,2) | Details |
| 16433889 | Bashir S, Sharma Y, Irshad M, Gupta SD, Dogra TD: Arsenic-induced cell death in liver and brain of experimental rats. Basic Clin Pharmacol Toxicol. 2006 Jan;98(1):38-43. Sodium arsenite was administered orally at doses of 6.3 mg/kg, 10.5 mg/kg and 12.6 mg/kg of body weight on the basis of a lethal dose 50% (LD50) for 24 hr. After administration of arsenites, liver and brain were analyzed for various parameters of oxidative stress, histopathological changes and caspase-3 activity. |
2(0,0,0,2) | Details |
| 19616567 | Ghosh J, Das J, Manna P, Sil PC: prevents arsenic-induced cardiac oxidative stress and apoptotic damage: role of NF-kappa B, p38 and JNK MAPK pathway. Toxicol Appl Pharmacol. 2009 Oct 1;240(1):73-87. Epub 2009 Jul 17. Arsenic reduced cardiomyocyte viability, increased reactive species (ROS) production and intracellular overload, and induced apoptotic cell death by mitochondrial dependent caspase-3 activation and poly-ADP polymerase (PARP) cleavage. |
2(0,0,0,2) | Details |
| 12503296 | Zeng L, Smith LD: Caspase-3 colorimetric assay. Biotechniques. 2002 Dec;33(6):1196-7. |
1(0,0,0,1) | Details |
| 15377153 | Lee CH, Yu CL, Liao WT, Kao YH, Chai CY, Chen GS, Yu HS: Effects and interactions of low doses of arsenic and UVB on keratinocyte apoptosis. Chem Res Toxicol. 2004 Sep;17(9):1199-205. The caspase-3, -8, and -9 relative activities were all increased in the UVB group; however, arsenic significantly enhanced caspase-8 and -3 relative activities in UVB-irradiated keratinocytes (the UVB-As group). Cultured human keratinocytes were treated with sodium arsenite (1 microM) and/or UVB (50 mJ/cm (2)) irradiation in different combinations: (i) arsenic alone, (ii) UVB alone, (iii) arsenic followed by UVB (As-UVB), and (iv) UVB followed by arsenic (UVB-As) treatments. |
1(0,0,0,1) | Details |
| 19082730 | Chowdhury R, Chowdhury S, Roychoudhury P, Mandal C, Chaudhuri K: Arsenic induced apoptosis in malignant melanoma cells is enhanced by through ROS generation, p38 signaling and p53 activation. Apoptosis. 2009 Jan;14(1):108-23. MATERIALS METHODS AND RESULTS: synergized NaAsO (2) to significantly increase ROS generation and facilitate the major apoptotic signaling events: alteration of mitochondrial membrane potential, cytochrome c release and anti-apoptotic protein Bcl-2 down-regulation and subsequent activation of caspase-9 and caspase-3 followed by poly-ADP- polymerase-1 cleavage. |
1(0,0,0,1) | Details |
| 19536524 | Wang Y, Xu Y, Wang H, Xue P, Li X, Li B, Zheng Q, Sun G: Arsenic induces mitochondria-dependent apoptosis by reactive species generation rather than depletion in Chang human hepatocytes. Arch Toxicol. 2009 Oct;83(10):899-908. Epub 2009 Jun 18. The MTT assay demonstrated that sodium arsenite (NaAsO2) treatment for 24 h caused a dose-dependent decrease of cell viability. NaAsO2 treatment (0-30 microM) was also found to induce externalization, a hallmark of apoptosis; to disrupt the mitochondrial membrane potential (Deltapsi ( m )); to cause the release of cytochrome c into the cytosol, and to trigger cleavage of caspase-3 and poly (ADP- polymerase (PARP) in a dose-dependent manner. |
1(0,0,0,1) | Details |
| 17645694 | Lin AM, Fang SF, Chao PL, Yang CH: attenuates arsenite-induced apoptosis in rat brain: involvement of mitochondrial and endoplasmic reticulum pathways and aggregation of alpha-synuclein. J Pineal Res. 2007 Sep;43(2):163-71. In the present study, the protective effect of on sodium arsenite (arsenite)-induced apoptosis was investigated. In the mitochondrial pathway, systemic inhibited arsenite-induced elevations in Bcl-2 and cytosolic cytochrome c as well as arsenite-induced reductions in procaspase-3 levels and elevations in active caspase-3 levels in the infused SN. |
1(0,0,0,1) | Details |