| Name | DHFR |
|---|---|
| Synonyms | DHFR; DHFRP 1; DHFRP1; Dihydrofolate reductase; Dihydrofolate reductases |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19766132 | Ruiz-Ramos R, Lopez-Carrillo L, Albores A, Hernandez-Ramirez RU, Cebrian ME: Sodium arsenite alters cell cycle and MTHFR, MT1/2, and c-Myc protein levels in MCF-7 cells. Toxicol Appl Pharmacol. 2009 Dec 15;241(3):269-74. Epub 2009 Sep 17. Therefore, our aim was to evaluate the effects of sodium arsenite on the protein levels of methylenetetrahydrofolate reductase (MTHFR) and dihydrofolate reductase (DHFR) and its further relationship with the expression MT1/2 and c-myc in MCF-7 cells. |
7(0,0,1,2) | Details |
| 2484623 | Barrett JC, Lamb PW, Wang TC, Lee TC: Mechanisms of arsenic-induced cell transformation. Biol Trace Elem Res. 1989 Jul-Sep;21:421-9. Both sodium arsenite and arsenate induced a high frequency of methotrexate-resistant 3T6 cells, which were shown to have amplified copies of the dihydrofolate reductase gene.(ABSTRACT TRUNCATED AT 250 WORDS) |
6(0,0,1,1) | Details |
| 3388020 | Lee TC, Tanaka N, Lamb PW, Gilmer TM, Barrett JC: Induction of gene amplification by arsenic. Science. 1988 Jul 1;241(4861):79-81. Two arsenic salts (sodium arsenite and arsenate) induced a high frequency of methotrexate-resistant 3T6 cells, which were shown to have amplified copies of the dihydrofolate reductase gene. |
6(0,0,1,1) | Details |
| 11368792 | Ding S, Yao D, Deeni YY, Burchell B, Wolf CR, Friedberg T: Human -P450 oxidoreductase modulates the level of cytochrome P450 CYP2D6 holoprotein via haem oxygenase-dependent and -independent pathways. Biochem J. 2001 Jun 1;356(Pt 2):613-9. In agreement with this, the activity of haem oxygenase, a rate-limiting enzyme in haem metabolism, was compared with that in DUKX/DHFR control cells (expressing dihydrofolate reductase), and was 3-fold higher in DUKX/2D6/CPR-3 but similar in DUKX/2D6 cells. Furthermore, treatment of cells with sodium arsenite increased levels of haem oxygenase concomitant with a marked decrease of spectrally detectable CYP2D6 and a rise in levels of ferritin, which sequesters free iron released from the destruction of haem. |
1(0,0,0,1) | Details |