| Name | thioredoxin reductase |
|---|---|
| Synonyms | ACR 1; PLP; ACR1; AOEB166; Alu corepressor 1; Antioxidant enzyme B166; B166; Liver tissue 2D page spot 71B… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9234670 | Bobrowicz P, Wysocki R, Owsianik G, Goffeau A, Ulaszewski S: Isolation of three contiguous genes, ACR1, ACR2 and ACR3, involved in resistance to arsenic compounds in the yeast Saccharomyces cerevisiae. Yeast. 1997 Jul;13(9):819-28. A 4.2 kb region from Saccharomyces cerevisiae chromosome XVI was isolated as a yeast fragment conferring resistance to 7 mM-sodium arsenite (NaAsO2), when put on a multicopy plasmid. |
5(0,0,0,5) | Details |
| 9027754 | Brown DM, Upcroft JA, Upcroft P: A thioredoxin reductase-class of disulphide reductase in the protozoan parasite Giardia duodenalis. Mol Biochem Parasitol. 1996 Dec 20;83(2):211-20. The sulphydryl-active compounds, N-ethylmaleimide, sodium arsenite and Zn2+ ions, strongly inhibited the enzyme suggesting that a thiol component forms part of the active site. |
4(0,0,0,4) | Details |
| 1575728 | Lenartowicz E: Ca (2+)-sensitive reduction of 5,5'-dithiobis-(2-nitrobenzoic acid) by rat liver mitochondria. Biochem Biophys Res Commun. 1992 Apr 30;184(2):1088-93. After lysis of mitochondria the reduction of DTNB required the addition of and EGTA and was inhibited by 1 mM sodium arsenite. These observations suggest that the reduction of DTNB by mitochondria is catalyzed by Ca (2+)-sensitive thioredoxin reductase (EC 1.6.4.5). |
1(0,0,0,1) | Details |
| 16111841 | Izquierdo-Vega JA, Soto CA, Sanchez-Pena LC, De Vizcaya-Ruiz A, Del Razo LM: Diabetogenic effects and pancreatic oxidative damage in rats subchronically exposed to arsenite. Toxicol Lett. 2006 Jan 5;160(2):135-42. Epub 2005 Aug 18. Male Wistar rats were administered sodium arsenite at 1.7 mg/kg (12 h), or water (controls) orally for 90 days. The activity of pancreatic thioredoxin reductase was lower than the control group. |
1(0,0,0,1) | Details |
| 18587442 | Talbot S, Nelson R, Self WT: Arsenic trioxide and auranofin inhibit selenoprotein synthesis: implications for chemotherapy for acute promyelocytic leukaemia. Br J Pharmacol. 2008 Jul;154(5):940-8. Epub 2008 Apr 21. Recently, As2O3 was shown to inhibit the activity of the selenoenzyme thioredoxin reductase (TrxR). |
1(0,0,0,1) | Details |
| 15695021 | Miyazaki K, Watanabe C, Mori K, Yoshida K, Ohtsuka R: The effects of gestational arsenic exposure and dietary selenium deficiency on and selenoenzymes in maternal and fetal tissues in mice. Toxicology. 2005 Mar 30;208(3):357-65. In the present study pregnant mice, fed either Se-deficient or adequate (0 or 5 micromol Se/kg diet, respectively) diet, were given oral gavage of sodium arsenite (0 or 58 micromol/kg per day; chosen as less than half of the fetotoxic dose in this protocol) from gestational day (GD) 7-16. The levels of As and Se as well as five selenoenzymes peroxidase (GPx), thioredoxin reductase (TRxR), and type-I, -II and -III iodothyronine deiodinases (DI-I, -II and -III) were examined on GD17 in the tissues of dams and of fetus. |
1(0,0,0,1) | Details |
| 2719637 | Flamigni F, Marmiroli S, Caldarera CM, Guarnieri C: Involvement of thiol transferase- and thioredoxin-dependent systems in the protection of 'essential' thiol groups of ornithine decarboxylase. Biochem J. 1989 Apr 1;259(1):111-5. In an attempt to investigate the physiological role of the 'essential' thiol group (s) of ODC, erythroleukaemia cells were incubated with NN-bis-(2-chloroethyl)-N'-nitrosourea, t-butyl hydroperoxide and vinblastine, which are known to increase the cellular /GSH ratio, an inhibitor of thioredoxin reductase, and sodium arsenite, a strong inhibitor of the ODC-re-activating factors. |
82(1,1,1,2) | Details |
| 6114827 | Anders MW, Ratnayake JH, Hanna PE, Fuchs JA: Thioredoxin-dependent sulfoxide reduction by rat renal cytosol. . Drug Metab Dispos. 1981 Jul-Aug;9(4):307-10. Furthermore, disulfides [insulin, and 5,5'-dithiobis (2-nitrobenzoic acid)] known to interact with thioredoxin-dependent enzyme systems inhibited sulindac reduction, as did sodium arsenite, a known inhibitor of thioredoxin reductase. |
81(1,1,1,1) | Details |